Effects of fluorosis on myocardial tissues and related signaling pathway changes
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Abstract
Fluorine is a common trace element that participates in the regulation of vital activities in human body. Proper intake of fluoride promotes the development of teeth and bones, prevents dental caries, and also benefits the conduction in the nervous system. However, long-term intake of excessive fluoride adversely affects various organ systems, especially the cardiovascular system. Chronic fluorosis is one common endemic disease in China. Long-term intake of excessive fluoride can cause different degrees of damage to the morphological structure and function of myocardium, and abnormal expressions of related signaling pathways. Therefore, exploring the changes of related signaling pathways in myocardial caused by fluorosis is important for the prevention and treatment of chronic fluorosis. The mitochondrial pathway of cell apoptosis involves multiple genes and signaling pathways. Oxidative stress plays an important role in fluoride-induced myocardial damage. This papaer reviewed the effects of fluorosis on myocardial tissues and discussed the changes of signaling pathways related to myocardial injury induced by fluorosis from the perspectives of oxidative stress and cell apoptosis, aiming to provide a theoretical basis for the prevention and treatment of fluorosis.
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