Research progress on effects of exposure to heavy metals on gut microbiome and associations of gut microbiome with related diseases in infants and children
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Abstract
With the rapid development of industrialization, the harmful effects of heave metal pollution on public health have drawn wide attention. More and more studies have shown that heavy metals can significantly change the composition and diversity of host's intestinal flora, break the proportion of intestinal flora, affect the metabolic activities of the body, and thus have various effects on human health. In particular, infancy and childhood are critical for rapid growth and development and the establishment of intestinal microbiota, and the toxic effects of heavy metals to their intestinal flora are more obvious. A large number of studies have shown that the disorder of intestinal flora is closely related to the occurrence and development of children's immune diseases, obesity, and autism, suggesting that the disorder of intestinal flora can affect children's later healthy growth. This paper reviewed studies on the effects of exposure to heavy metals including lead, arsenic, cadmium, and mercury on the intestinal flora of infants and children, as well as the associations between intestinal flora and pediatric diseases, aiming to provide a direction for further research on the mechanism of negative health impacts by heavy metals.
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