WANG Jun-dong, WANG Yi-wen, GAO Yong-ling, ZHENG Hai-xia, ZHOU Yi-jun, ZHANG Yan, SHI Rong, TIAN Ying. Organophosphate pesticides exposure levels in pregnant women and children from Laizhou Bay Birth Cohort[J]. Journal of Environmental and Occupational Medicine, 2018, 35(5): 423-427. DOI: 10.13213/j.cnki.jeom.2018.17722
Citation: WANG Jun-dong, WANG Yi-wen, GAO Yong-ling, ZHENG Hai-xia, ZHOU Yi-jun, ZHANG Yan, SHI Rong, TIAN Ying. Organophosphate pesticides exposure levels in pregnant women and children from Laizhou Bay Birth Cohort[J]. Journal of Environmental and Occupational Medicine, 2018, 35(5): 423-427. DOI: 10.13213/j.cnki.jeom.2018.17722

Organophosphate pesticides exposure levels in pregnant women and children from Laizhou Bay Birth Cohort

  • Objective To determine the organophosphate pesticides (OPs) exposure levels in pregnant women and children at 24 months of age from Laizhou Wan (Bay) Birth Cohort (LWBC) in Shandong.

    Methods The present study was a part of a longitudinal birth cohort study in the southern coastal area of Laizhou Wan (Bay) of the Bohai Sea, Shandong Province, China. Pregnant women (n=436) were recruited to complete a questionnaire survey and to collect random spot urine samples. They were followed up until their children were 24 months of age to collect children's urine samples (n=239). Non-specific OPs metabolites, including diethyldithiophosphate (DEDTP), diethylthiophosphate (DETP), diethylphosphate (DEP), dimethyldithiophosphate (DMDTP), dimethylthiophosphate (DMTP), and dimethylphosphate (DMP), in mothers' and children's urine samples were detected by gas chromatography-mass spectrometry. Correlations of the non-specific OPs metabolites mother's and children's urine samples were analyzed by Spearman correlation analysis.

    Results The creatinine-adjusted levels in 436 maternal urine samples were 11.41 μg/g for DEP, 1.93 μg/g for DETP, 21.42 μg/g for DMP, and 2.24 μg/g for DMTP, respectively. The levels in 239 twenty-four-month-old children's urine samples were 16.65 μg/g for DEP, 3.95 μg/g for DETP, 38.68 μg/g for DMP, and 3.48 μg/g for DMTP, respectively. A negative correlation was found between DEP levels in maternal and children's urine samples (r=-0.149, P=0.021).

    Conclusion The pregnant women and children from the Laizhou Bay Birth Cohort show high exposure levels of OPs, requiring concerns.

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