YANG Shu, YANG Fei, FENG Xiang-ling, CHEN Ji-hua, WEN Cong, CHEN Lü. Review on role of non-coding RNA in microcystin-LR toxicity[J]. Journal of Environmental and Occupational Medicine, 2018, 35(1): 83-88. DOI: 10.13213/j.cnki.jeom.2018.17592
Citation: YANG Shu, YANG Fei, FENG Xiang-ling, CHEN Ji-hua, WEN Cong, CHEN Lü. Review on role of non-coding RNA in microcystin-LR toxicity[J]. Journal of Environmental and Occupational Medicine, 2018, 35(1): 83-88. DOI: 10.13213/j.cnki.jeom.2018.17592

Review on role of non-coding RNA in microcystin-LR toxicity

  • Microcystin-LR (MC-LR) is one of the most toxic microcystins produced by cyanobacteria, posing a serious threat to ecological environment and public health. Previous studies have shown that MC-LR may cause toxicity by inhibiting protein phosphatase activity and inducing oxidative stress and DNA damage. However, the associated mechanism of its toxicity remains unclear. Noncoding RNA (ncRNA) is a class of RNA molecules that do not encode proteins, playing an important role in mediating inflammation, tumor genesis and development, and the toxicity of exogenous chemicals. Recent studies have shown that ncRNA is involved in the regulation of MC-LR toxicity. This paper reviewed the role of ncRNA in mediating MC-LR toxicity, aiming to provide an insight for further study on the mechanism of MC-LR toxicity.

  • loading

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return