Research progress on detection methods for polybrominated diphenyl ethers and their metabolites in biological samples
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Abstract
Polybrominated diphenyl ethers (PBDEs), as additive brominated flame retardants, are widely used in a variety of in dustrial and commercial products. PBDEs are persistent organic pollutants with environmental endocrine disruption effect, neurotoxicity, and reproductive toxicity. PBDEs can be metabolized into hydroxylated PBDEs (OH-PBDEs) and methylated into methoxylated PBDEs (MeO-PBDEs) in vivo. Recently, PBDEs and their metabolites (OH-PBDEs, MeO-PBDEs) and bromophenols have raised social concerns due to the detection of above-mentioned chemicals in environment and organisms. In this review, the exposure levels and the methods of pretreatment and detection of PBDEs and their metabolites in environment and human body were summarized, aiming to provide methodological references for the exposure assessment and toxicological research of PBDEs.
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