Research advance on association between prenatal exposure to polybrominated diphenyl ethers and fetal dysplasia
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Abstract
Polybrominated diphenyl ethers (PBDEs), a group of brominated flame retardants, are widely added into composite materials to improve flame retardancy. PBDEs continually release to environment during the production, use, and disposal of relevant products. Recent animal experiments and human epidemiological studies show that prenatal exposure to PBDEs and their metabolites may have adverse effects on fetal development (including birth length, birth weight, and newborn body mass index). In this paper, the published studies on metabolic transformation of PBDEs in vivo and correlations between prenatal PBDEs exposure and fetal growth were reviewed. The sources of PBDEs metabolites could be natural source, PBDEs metabolic transformation, maternal transformation, and transformation of other PBDEs metabolites. Prenatal exposure to PBDEs was associated with low birth weight, shortened birth length, premature, and other adverse outcomes. PBDEs exposure during pregnancy might affect fetal growth and development by modulating various growth factors in placenta.
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