Research advance on reproductive toxicity of manganese in males
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Abstract
Manganese is a metal element widely existing in nature and an essential trace element for human body. It is heavily used in agricultural and industrial production. Recent studies suggest effects of manganese on male reproductive toxicity. It can damage testis tissue, decrease sperm number and vitality, induce apoptosis of germ cells, alter enzyme activity, and interfere with reproductive hormone levels. Manganese exposure routes, effects on male reproductive system, and related mechanisms were reviewed in this article. It is suggested that the signaling pathway related mechanism of manganese induced apoptosis in germ cells should be studied in order to provide evidence for the prevention and treatment of male reproductive damage caused by manganese.
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