Review on associations between ambient fine particulate matters and type 2 diabetes mellitus
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Abstract
In recent years, fine particulate matters (PM2.5) have become a major concern in many cities in China. Type 2 diabetes mellitus, a typical chronic metabolic disorder, has shown an increasing prevalence in China and across the world, posing heavy burdens to both patients and society. In this review, we analyzed recent population-based epidemiological and toxicological studies on PM2.5 and type 2 diabetes, and drew following conclusions. Exposure to ambient PM2.5 could increase the risk of having type 2 diabetes mellitus. The potential mechanisms attributed to the adverse health effect were oxidative stress and inflammatory response in insulin target tissues or the mitochondrial dysfunction in specific signal pathways intrigued by toxic substances carried by PM2.5 which are prone to absorb hazardous substances, leading to glucose metabolism disorders and finally inducing or aggravating diabetes.
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