Mitochondrial DNA copy number: a new biomarker of occupational and environmental exposure
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Abstract
Mitochondria is the common poison target of environmental and occupational chemicals, and related mitochondrial functional and structural changes may become early markers of chemical exposures. In this review, the variations of peripheral mitochondrial DNA copy number (mtDNAcn) were assessed after exposure to environmental and occupational chemicals. mtDNAcn was increased after exposure to chemicals such as benzene, dimethylformamide, and polycyclic aromatic hydrocarbons. However, a long-term exposure to air particles or tobacco smoke led to a decrease of mtDNAcn. Thus, mtDNAcn responses would differ depending on chemicals, exposure time, and exposure dose. The application of mtDNAcn to surveillance of early effects of occupational and environmental chemicals is worth investigating.
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