CHEN Jing-si, GAO Xi, GUO Jia-lin, WU Min, LI Shu-guang, SUN Jing, CHEN Bo. Assessment on cumulative health risk of phthalic acid esters in meconium of 237 Shanghai newborns[J]. Journal of Environmental and Occupational Medicine, 2017, 34(5): 379-384. DOI: 10.13213/j.cnki.jeom.2017.16815
Citation: CHEN Jing-si, GAO Xi, GUO Jia-lin, WU Min, LI Shu-guang, SUN Jing, CHEN Bo. Assessment on cumulative health risk of phthalic acid esters in meconium of 237 Shanghai newborns[J]. Journal of Environmental and Occupational Medicine, 2017, 34(5): 379-384. DOI: 10.13213/j.cnki.jeom.2017.16815

Assessment on cumulative health risk of phthalic acid esters in meconium of 237 Shanghai newborns

  • Objective To describe the exposure levels of phthalic acid esters (PAEs) in newborns in Shanghai and assess the cumulative health risk due to the exposure.

    Methods A cross-sectional study was conducted in 237 newborns delivered in Shanghai First Maternity and Infant Hospital of Tongji University form July 2013 to July 2014. Ten kinds of phthalate metabolitesmonomethyl phthalate (MMP), monoethylphthalate (MEP), mono-n-butylphthalate (MnBP), monoisobutylphthalate (MiBP), mono-benzylphthalate (MBzP), mono-2-ethylhexylphthalate (MEHP), mono-2-ethyl-5-oxohexyphthalate (MEOHP), mono-2-ethyl-5-hydroxyhexylphthalate (MEHHP), mono-2-ethyl-5-carboxypentylphthalate (MECPP), and mono-2-carboxymethyl-hexyl phthalate (MCMHP) in meconium samples were determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Estimated daily intakes (EDI) of six kinds of PAEsdimethyl phthalate (DMP), diethyl phthalate (DEP), diisobutyl phthalate (DiBP), di-n-butyl phthalate (DnBP), butyl-benzyl phthalate (BBP), and di-2-ethylhexyl phthalate (DEHP) were calculated through the mass fractions of phthalate metabolites. The cumulative health risks of PAEs were assessed using hazard index (HI) approach.

    Results MEHP, MiBP, and MnBP were three highest phthalate metabolites detected in the meconium samples in terms of both detection rates (all > 90%) and mass fractions (65.00, 27.30, and 27.90 ng/g, respectively). The median of EDI of DiBP (22.88 μg/kg body weight) was higher than those of DEP, DnBP, DMP, DEHP, and BBP, with medians of 3.45, 2.96, 1.90, 1.19, and 0.41 μg/kg body weight, respectively. There were 2.11% of the participants (n=5) with HI ≥ 1.

    Conclusion There are 2.11% of the selected newborns with HI ≥ 1, indicating the PAEs exposure in Shanghai newborns may pose a health risk to them.

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