CHEN Wei, LI Tian-ya, ZHANG Ru-hong, ZHANG Qun. Case-control study on associations between parental environmental exposure during peri-conceptional period and microtia in children 0-10 years of age[J]. Journal of Environmental and Occupational Medicine, 2017, 34(4): 285-290. DOI: 10.13213/j.cnki.jeom.2017.16700
Citation: CHEN Wei, LI Tian-ya, ZHANG Ru-hong, ZHANG Qun. Case-control study on associations between parental environmental exposure during peri-conceptional period and microtia in children 0-10 years of age[J]. Journal of Environmental and Occupational Medicine, 2017, 34(4): 285-290. DOI: 10.13213/j.cnki.jeom.2017.16700

Case-control study on associations between parental environmental exposure during peri-conceptional period and microtia in children 0-10 years of age

  • Objective To assess the associations of parental exposure to potential environmental or occupational risk factors from 6 months prior to conception to the first trimester of pregnancy (peri-conceptional period) with the occurrence of isolated microtia.

    Methods A case-control study was performed in Shanghai Ninth People's Hospital from June 2015 to June 2016. Personal interviews and questionnaire surveys were conducted among the parents of children aged 0-10 years with diagnosed congenital microtia (case group) and traumatic injuries/other emergent conditions (control group). Their demographic information, residential environment, living habits, and occupational exposure during peri-conceptional period were collected for chi-square test and nonconditional multiple logistic regression analysis.

    Results A total of 124 cases and 126 controls were included for analysis. The results of chi-square test showed that parental exposure to industrial pollution (such as sewage, solid waste, and air pollutants) near residence (≤ 3 km2), indoor decoration, and new furniture in residence during peri-conceptional period, maternal exposure to heavy metals at workplace, hair dyeing or perming, and passive smoking during peri-conceptional period, as well as paternal occupational exposure to heavy metals and organic solvent might be the risk factors of congenital microtia (P < 0.05). The results of non-conditional multiple logistic regression analysis showed that maternal factors including lower educational level (OR=0.737, 95%CI: 0.545-0.996), indoor decoration during peri-conceptional period (OR=4.546, 95%CI: 1.668-12.390), and more passive smoking exposure during peri-conceptional period (OR=1.420, 95%CI: 1.059-1.903), as well as paternal exposure to heavy metals at workplace (OR=2.880, 95%CI: 1.036-8.007) might be the risk factors for microtia.

    Conclusion The impacts of exposure to various environmental and occupational risk factors during peri-conceptional period on the occurrence of microtia deserve more attention and further study.

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