GUO Ji-peng, ZHANG Yunbo, DONG Jin, ZHANG Xiao, DONG Xin-wen, NA Xiao-lin. Effect of maternal genistein intervention on obesity of male offspring rats[J]. Journal of Environmental and Occupational Medicine, 2017, 34(5): 441-444. DOI: 10.13213/j.cnki.jeom.2017.16629
Citation: GUO Ji-peng, ZHANG Yunbo, DONG Jin, ZHANG Xiao, DONG Xin-wen, NA Xiao-lin. Effect of maternal genistein intervention on obesity of male offspring rats[J]. Journal of Environmental and Occupational Medicine, 2017, 34(5): 441-444. DOI: 10.13213/j.cnki.jeom.2017.16629

Effect of maternal genistein intervention on obesity of male offspring rats

  • Objective To examine the potential effect of maternal genistein intervention on obesity of male offspring rats.

    Methods Mature female rats were given different doses of genistein (3 600, 1 200, and 400 mg/kg feed, respectively) during pregnancy and lactation. A control group fed without genistein was set up. Offspring rats after weaning were fed no-genistein diet for eight weeks. The body weight of male offspring rats was observed once a week during the experiment. Lee's index and ratio of fat/body weight were calculated after the experiment. Blood lipid, blood glucose, insulin, and inflammatory factors in serum samples were detected.

    Results After eight weeks, compared with the control group, the male offspring rats following maternal 3 600 mg/kg genistein treatment showed reduced body weight (P=0.028) and increased high-density lipoprotein cholesterol (P=0.038); those following maternal 3 600 mg/kg and 1 200 mg/kg genistein treatment showed decreased Lee's index, total wet weight of fat, and blood glucose (P=0.031, P=0.049; P=0.009, P=0.016; P=0.033, P=0.026). No obvious changes in insulin and cytokines were found in the offspring rats with maternal genistein treatment.

    Conclusion Maternal genistein intake during pregnancy and lactation could reduce the occurrence of offspring obesity.

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