Objective To study the relationship between polymorphism of angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) genotype and essential hypertension (EH) in Han ethnic group in China.
Methods Twenty-nine eligible papers reported the association between polymorphism of ACE gene and EH patients in Han ethnic group in China from January 2000 to January 2016, which included 5 485 cases and 4 878 healthy controls. The data of case and control groups' genotypes and alleles were extracted. Combined effect values were derived by fixed or random effect model and used to test and adjust publication bias using Stata 12.0 software.
Results The pooled OR for ID genotype and DD genotype versus II genotype were 1.05 (95%CI:0.92-1.19) and 1.66 (95%CI:1.34-2.05), respectively. The pooled OR for D allele versus I allele was 1.25 (95%CI:1.12-1.40). The results of funnel plot, Egger's test, and fail-safe number showed minor publication bias in the present meta-analysis.
Conclusion Bearing DD genotype and D allele of ACE gene may associate with a higher risk of EH in Han ethnic group in China.
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