甄玲燕, 蒋蓉芳, 辛峰, 王广鹤, 吕鹏, 宋伟民. 大气细颗粒物对自发性高血压大鼠心血管系统的影响[J]. 环境与职业医学, 2013, 30(6): 471-474.
引用本文: 甄玲燕, 蒋蓉芳, 辛峰, 王广鹤, 吕鹏, 宋伟民. 大气细颗粒物对自发性高血压大鼠心血管系统的影响[J]. 环境与职业医学, 2013, 30(6): 471-474.
ZHEN Ling-yan , JIANG Rong-fang , XIN Feng , WANG Guang-he , LÜ Peng , SONG Wei-min . Effects of Airborne Fine Particulate Matters on Cardiovascular System of Spontaneously Hypertensive Rats[J]. Journal of Environmental and Occupational Medicine, 2013, 30(6): 471-474.
Citation: ZHEN Ling-yan , JIANG Rong-fang , XIN Feng , WANG Guang-he , LÜ Peng , SONG Wei-min . Effects of Airborne Fine Particulate Matters on Cardiovascular System of Spontaneously Hypertensive Rats[J]. Journal of Environmental and Occupational Medicine, 2013, 30(6): 471-474.

大气细颗粒物对自发性高血压大鼠心血管系统的影响

Effects of Airborne Fine Particulate Matters on Cardiovascular System of Spontaneously Hypertensive Rats

  • 摘要: 目的 观察气管滴注大气细颗粒物(PM2.5)对自发性高血压大鼠(SHR)心血管系统的影响。

    方法 将24 只雄性SPF 大鼠随机分为生理盐水对照组及PM2.5 染毒低、中、高剂量(分别为1.6、8.0、40.0 mg/kg 体重)组, 各剂量组均经气管滴注染毒3 d。末次染毒24 h 后, 监测记录大鼠的血压、心率和心电图, 取腹主动脉血测定大鼠血浆内皮素1(ET-1)、P-选择素和D-二聚体浓度。

    结果 与对照组相比, PM2.5 各染毒剂量组血压和心率均升高(P < 0.05), 心率变异性降低(P < 0.05), 大鼠血浆ET-1 水平明显升高(P < 0.05)。中、高剂量PM2.5 暴露可引起大鼠血浆P-选择素和D-二聚体水平明显升高(P < 0.05)。

    结论 PM2.5 气管滴注可导致大鼠心脏自主神经功能异常并改变凝血纤溶的平衡。

     

    Abstract: Objective To study changes in cardiovascular system of spontaneously hypertensive rats exposed to fine particulate matters (PM2.5).

    Methods Twenty-four SPF male spontaneously hypertensive rats were randomly divided into 4 groups including 1 saline control group and 3 PM2.5 exposure groups (1.6, 8.0, and 40.0 mg/kg body weight, respectively). Each exposure group received intratracheal instillation once per day for 3 consecutive days. At the 24 h after the last administration, blood pressure, heart rate, and cardiogram were recorded, and blood samples were collected to analyze the concentration of plasma endothelin 1 (ET-1), P-selection, and D-dimmer.

    Results The blood pressure and the heart rate increased significantly and the heart rate variability decreased significantly in the PM2.5-treated rats compared with the control group (P<0.05). Elevated plasma ET-1 levels were observed in the 3 PM2.5 exposure groups (P<0.05). The P-selection and the D-dimmer increased significantly in the 8.0 and 40.0 mg/kg PM2.5 exposure groups (P<0.05).

    Conclusion Exposure to PM2.5 induce changes in autonomic nervous function and blood coagulation & fibrinolysis in rats.

     

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