王斌, 李金花, 汪国权. 衍生-顶空气相色谱法测定化妆品中游离甲醛[J]. 环境与职业医学, 2012, 29(7): 459-461.
引用本文: 王斌, 李金花, 汪国权. 衍生-顶空气相色谱法测定化妆品中游离甲醛[J]. 环境与职业医学, 2012, 29(7): 459-461.
WANG Bin , LI Jin-hua , WANG Guo-quan . Determination of Dissociate Formaldehyde in Cosmetics by Derivatization-Headspace-Gas Chromatography[J]. Journal of Environmental and Occupational Medicine, 2012, 29(7): 459-461.
Citation: WANG Bin , LI Jin-hua , WANG Guo-quan . Determination of Dissociate Formaldehyde in Cosmetics by Derivatization-Headspace-Gas Chromatography[J]. Journal of Environmental and Occupational Medicine, 2012, 29(7): 459-461.

衍生-顶空气相色谱法测定化妆品中游离甲醛

Determination of Dissociate Formaldehyde in Cosmetics by Derivatization-Headspace-Gas Chromatography

  • 摘要: 目的 以五氟苯肼(PFPH)衍生化,建立简单、高效的化妆品中游离甲醛的衍生-顶空气相色谱测定方法,以满足实验室日常检测的需要。

    方法 采用水进行液-液提取,用PFPH进行衍生,顶空气相色谱进行分离,氢火焰离子化检测器进行检测。

    结果 通过衍生能有效去除干扰,该方法加标浓度在8.0~40.0 mg/kg 范围内,平均回收率为106%,精密度范围为1.8%~5.2%(n=6)。方法检出限为0.6 mg/kg。

    结论 本方法测定化妆品中游离甲醛,快速、简单、可靠,可满足实验室日常检测需要。

     

    Abstract: Objective To establish a simple and efficient method for determination of dissociate formaldehyde in cosmetics samples by derivatization-headspace-gas chromatography, and to meet requirements of daily inspections.

    Methods Dissociate formaldehydes were extracted by liquid-liquid extraction technique using water and derivatized with pentafluorop henylhydrazine (PFPH). The derivatives were separated by gas chromatography and measured by hydrogen flame ionization detector.

    Results The derivatization reaction effectively removed interferences. The spiked concentrations of this method were 8.0-40.0 mg/kg. The average recovery was 106% and the relative standard deviation (RSD) ranged from 1.8% to 5.2% (n=6). The detection limit was 0.6 mg/kg.

    Conclusion This method for dissociate formaldehyde determination in cosmetics is simple, quick and accurate. It can meet routine laboratory testing requirements.

     

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