马国云, 李真观, 王炳森, 郭根来, 闵嗣蕴, 李世俊. 生产性含镍粉尘致癌作用的实验病理观察[J]. 环境与职业医学, 2012, 29(5): 318-320.
引用本文: 马国云, 李真观, 王炳森, 郭根来, 闵嗣蕴, 李世俊. 生产性含镍粉尘致癌作用的实验病理观察[J]. 环境与职业医学, 2012, 29(5): 318-320.
MA Guo-yun , LI Zhen-guan , WANG Bing-sen , GUO GEN-LAI , MIN Si-yun , LI Shi-jun . Pathological Observation on Inhalation Carcinogenicity of Industrial Nickel Dust in Rats[J]. Journal of Environmental and Occupational Medicine, 2012, 29(5): 318-320.
Citation: MA Guo-yun , LI Zhen-guan , WANG Bing-sen , GUO GEN-LAI , MIN Si-yun , LI Shi-jun . Pathological Observation on Inhalation Carcinogenicity of Industrial Nickel Dust in Rats[J]. Journal of Environmental and Occupational Medicine, 2012, 29(5): 318-320.

生产性含镍粉尘致癌作用的实验病理观察

Pathological Observation on Inhalation Carcinogenicity of Industrial Nickel Dust in Rats

  • 摘要: 目的 探讨生产性含镍粉尘的致癌作用。

    方法 Wistar雄性大鼠随机分为 3组:选矿组和冶炼组分别暴露于镍选矿及冶炼车间, 自然吸入粉尘, 正常对照组饲养于职工医院生活区。实验全程历时 2年, 结束后对大鼠做详细的病理组织学检查。

    结果 现场暴露共诱发肺部肿瘤 4例, 选矿组 1例为肺腺癌(检出率为 14.3%), 冶炼组 3例(其中 2例肺腺癌, 1例肺鳞癌), 检出率为 42.9%。肺部肿瘤平均潜伏期为 20.5个月。

    结论 吸入镍冶炼车间粉尘有一定程度致癌作用, 选矿车间粉尘致癌作用较弱。

     

    Abstract: Objective To study the carcinogenicity of industrial nickel dust in rats by inhalation study.

    Methods Male Wistar rats were divided into 3 groups:2 test groups were exposed to mineral dust at scintillation site and dust at smelt site respectively for 2 years; and 1 control group was raised at non-exposure area with normal feeding. Histopathological examinations were then carried out on the rats survived or died during the experiment.

    Results A total of 4 cases of pulmonary tumors were induced in 2 test groups:1 pulmonary adenocarcinoma case in mineral dust group (positive rate was 14.3%); 2 pulmonary adenocarcinoma cases and 1 pulmonary squamous cell carcinoma case in smelt dust group (positive rate was 42.9%). The average latency period for lung cancer was 20.5 months.

    Conclusion Industrial nickel dust in smelting workshops may be carcinogenic to rat, and that in ore scintillation workshops may possess weaker carcinogenic activity.

     

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