石化企业工人膀胱癌职业危险因素的病例对照研究
Occupational Risk Factors of Bladder Cancer among Petrochemical Workers: A Matched Case Control Study
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摘要:
目的 探讨石化企业工人膀胱癌的职业危险因素。 方法 对 21例膀胱癌病人按年龄、性别、民族进行 1:4匹配, 年龄相差不超过 3岁, 采用自行设计的调查表调查膀胱癌的危险因素, 所得资料利用 SAS 8.0、Excel 2003等软件进行单因素和多因素条件 logistic回归分析。 结果 单因素分析显示化工岗位工人患膀胱癌危险性是非化工岗位工人的 8倍, 95%可信区间为 1.465~43.678; 暴露工龄越长, 其发生膀胱癌的危险性越大。多因素分析同样证实化工岗位是化工企业工人膀胱癌的职业危险因素。 结论 从事化工岗位工作及暴露工龄长是使石化企业工人膀胱癌危险性增加的两个主要职业因素。 Abstract:Objective To explore the occupational risk factors of bladder cancer in petrochemical enterprises. Methods In this matched case control study, 21 bladder cancer cases were enrolled, each matched with 4 controls on gender, ethnicity and age (within 3 years). Information about potential bladder cancer risk factors was collected through a self-designed questionnaire. Conditional logistic regression analysis was conducted with SAS 8.0 and Excel 2003. Results Univariate analysis showed that workers with chemical exposure was 8 times (95% confidence interval:1.465-43.678) as likely to develop bladder cancer as those without, and longer working years was associated with higher risks of bladder cancer also. Multivariate analysis also validated that job with chemical processing in petrochemical enterprises was a risk factor of bladder cancer. Conclusion Bladder cancer is occupationally related to job position in chemical work and extended length of exposure.
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