Abstract: Bisphenol A(BPA) is an well-known environmental endocrine disrupter, with both estrogenic activity and antiandrogenic activity, which is harmful to parents' reproductive system and subsequently to offspring's growth and development. Whether low-dose BPA exposure (below 50 mg/kg/day) can cause adverse effects on reproductive system, brain, and behavior is widely studied in recent years. The reference dose (50 μg/kg/day) established by the United States and the European Union arouses considerable debate. This paper reviewed in vivo experiments and epidemiological studies on BPA to understand the possible adverse health outcomes of BPA exposure.