学龄儿童尿中8-羟基脱氧鸟苷水平与交通干道大气污染关系的研究
Study on the Relationship between Traffic Artery Air Pollution and Urine 8-OH-dG Level in Schoolchildren
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摘要:
目的 探讨健康学龄儿童尿8-羟基脱氧鸟苷(8-OH-dG)水平及其与交通干道大气污染之间的关系。 方法 选择距离交通干道约30 m的某小学及符合入选标准的30名学龄儿童作为研究对象。分别于2008年5月份和11月份,在该小学操场的区域监测点各进行1次连续5 d的区域氮氧化物(NOX)、SO2、O3、细颗粒物(PM2.5)污染水平检测;对学龄儿童活动点(课堂教学区、课外活动区、家校往返途中)的NO2、SO2、O3、颗粒物(PM10)污染水平各进行1次连续3 d的监测,并对学龄儿童尿液8-OH-dG含量各进行1次检测。 结论 5月份和11月份区域监测结果显示,所测各污染物污染负荷系数最大的为PM2.5和NOX,PM2.5的污染负荷系数分别为0.33和0.27,NOX分别为0.31和0.26。与5月份相比,11月份学龄儿童尿8-OH-dG水平明显升高(P<0.001)。个体暴露各污染物水平与学龄儿童尿8-OH-dG水平呈正相关,均有统计学意义(P<0.001),其中个体暴露PM10与8-OH-dG的回归系数最大(βPM10=0.40、βNO2=0.38、βO3=0.36、βSO2=0.36)。 结论 交通干道大气污染的暴露可能是学龄儿童尿8-OH-dG水平的影响因素。 Abstract:Objective To explore whether pollutants exposure has a measurable impact on urine 8-OH-dG level of healthy schoolchildren in traffic artery air polluted region. Methods A primary school near the trunk road with a distance about 30 meters was selected, from which 30 schoolchildren fit the qualifications were selected as the objects. The pollution le vels of SO2, NOX, O3 and PM2.5 were consecutively detected for five days in May and November, 2008 at the regional monitoring site in the playground. The pollution levels of SO2, NO2, O3 and PM10 were consecutively detected for 3 days in the same months at schoolchildren's activity places(classroom sites, extracurricular activity sites and sites on the way to school). Urine 8-OHdG content of the schoolchildren was also measured. Results The regional monitoring results showed that the pollution load coefficient of PM2.5 were 0.33 and 0.27 in May and November respectively, of NOX were 0.31 and 0.26, the two pollutants formed the biggest pollution load coefficients. Compared to May, the value of urine 8-OH-dG of schoolchildren increased with statistically significant difference in November (P<0.001). Urine 8-OH-dG level positively correlated with personal exposure to environmental pollutants with statistically significant difference (P<0.001), in which PM10 showed the largest regression coefficient (βPM10=0.40, βNO2=0.38, βO3=0.36, βSO2=0.36). Conclusion Exposure to traffic artery air pollution may be the influencing factor affecting urine 8-OH-dG level in healthy schoolchildren.
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