李隐侠, 王大勇. 基于秀丽线虫发育时期敏感性差异进行的环境暴露安全性评价研究进展[J]. 环境与职业医学, 2011, 28(10): 621-626.
引用本文: 李隐侠, 王大勇. 基于秀丽线虫发育时期敏感性差异进行的环境暴露安全性评价研究进展[J]. 环境与职业医学, 2011, 28(10): 621-626.
LI Yin-xia , WANG Da-yong . Advances in the Toxicity Evaluation of Environmental Exposure based on Caenorhabditis Elegans at Different Developmental Stages[J]. Journal of Environmental and Occupational Medicine, 2011, 28(10): 621-626.
Citation: LI Yin-xia , WANG Da-yong . Advances in the Toxicity Evaluation of Environmental Exposure based on Caenorhabditis Elegans at Different Developmental Stages[J]. Journal of Environmental and Occupational Medicine, 2011, 28(10): 621-626.

基于秀丽线虫发育时期敏感性差异进行的环境暴露安全性评价研究进展

Advances in the Toxicity Evaluation of Environmental Exposure based on Caenorhabditis Elegans at Different Developmental Stages

  • 摘要: 目前,模型动物秀丽线虫已经广泛应用于环境安全评价和环境毒理研究。本文系统综述基于致死率、生殖、运动行为、神经元存活与发育、神经突触活性、肠道自发荧光、应激反应等评价终点进行的秀丽线虫各个发育时期对于环境暴露敏感性差异的研究进展,并总结现有的3种用于分析秀丽线虫各个发育时期对于环境暴露敏感性的方法,进而讨论基于秀丽线虫发育时期的敏感性差异进行环境暴露安全性评价研究中尚存在的问题以及可能的解决策略。

     

    Abstract: So far, the model animal of Caenorhabditis elegans has been widely used in the studies of environmental safety evaluation and toxicology. In this paper, we reviewed the progresses on sensitivity to environmental exposure of Caenorhabditis elegans at different developmental stages using the lethality, reproduction, locomotion behavior, neuronal survival and development, synaptic activity, intestinal autofluorescence, and stress response as evaluation endpoints. Moreover, three methods used to analyze the sensitivity of Caenorhabditis elegans at different developmental stages to environmental exposure were summarized. Furthermore, the questions needed to be further solved for applications of Caenorhabditis elegans at different developmental stages in evaluation of environmental exposure have been discussed, and the related suggestions have also been provided.

     

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