王来, 耿慧霞, 蒋建平. 孕期吸烟与先天性腹裂胎儿关系的Meta分析[J]. 环境与职业医学, 2010, 27(12): 716-718.
引用本文: 王来, 耿慧霞, 蒋建平. 孕期吸烟与先天性腹裂胎儿关系的Meta分析[J]. 环境与职业医学, 2010, 27(12): 716-718.
WANG Lai , GENG Hui-xia , JIANG Jian-ping . A Meta-analysis on the Association between Materal Smoking during Pregnancy and Prenatal Gastroschisis[J]. Journal of Environmental and Occupational Medicine, 2010, 27(12): 716-718.
Citation: WANG Lai , GENG Hui-xia , JIANG Jian-ping . A Meta-analysis on the Association between Materal Smoking during Pregnancy and Prenatal Gastroschisis[J]. Journal of Environmental and Occupational Medicine, 2010, 27(12): 716-718.

孕期吸烟与先天性腹裂胎儿关系的Meta分析

A Meta-analysis on the Association between Materal Smoking during Pregnancy and Prenatal Gastroschisis

  • 摘要: 目的 探讨孕期吸烟与先天性腹裂胎儿的关系,分析不同孕期和每天不同吸烟量对先天性腹裂的影响。

    方法 分别检索6个中英文文献数据库,选择6篇符合纳入标准的文献,通过Review Manager 4.2和Stata软件进行Meta分析。

    结果 孕期吸烟与先天性腹裂胎儿之间的合并效应值为OR=2.36(95%CI:2.02~2.76);每天吸烟量为10~20支及> 20支的合并效应值分别为OR=2.29(95% CI:1.89~2.77)和OR=2.54(95% CI:1.68~3.85),吸烟量<10支的无统计学意义;孕期前三个月吸烟的合并效应值为OR=2.46(95%CI:1.52~3.98)。

    结论 孕期吸烟尤其孕期前三个月吸烟与先天性腹裂胎儿具有显著相关性,此相关性随每天吸烟量的增加而增大。

     

    Abstract: Objective To examine the association between maternal smoking during pregnancy and prenatal gastroschisis, also to investigate the effects of different pregnancy phases and the amount of smoking per day on gastroschisis.

    Methods Totally six studies published in Chinese and English literature databases were analyzed synthetically by Meta analysis through the Review Manager 4.2 and Stata software.

    Results The combined effect value of odds ratio (OR) between smoking during pregnancy and gastroschisis was 2.3695% confidence interval (CI):2.02-2.76. The combined effect value of OR was 2.29 (95%CI:1.89-2.77) when the number of cigarettes smoked per day was between 10 to 20, and 2.54 (95%CI:1.68-3.85) when more than 20. There was no statistical significance of the OR value when cigarettes smoked less than 10 per day. The value of OR was 2.46 (95%CI:1.52-3.98) when women were smoking during the first three months of their pregnancy.

    Conclusion Smoking in the first three months during pregnancy had significant correlation with prenatal gastroschisis, and this correlation in creased with the increasing daily smoking amount.

     

/

返回文章
返回