王金, 王颖, 李培帅, 秦萌, 蒋守芳, 佟俊旺. CYP11B2基因多态性对高温作业钢铁工人原发性高血压易感性的影响[J]. 环境与职业医学, 2019, 36(9): 831-835. DOI: 10.13213/j.cnki.jeom.2019.19293
引用本文: 王金, 王颖, 李培帅, 秦萌, 蒋守芳, 佟俊旺. CYP11B2基因多态性对高温作业钢铁工人原发性高血压易感性的影响[J]. 环境与职业医学, 2019, 36(9): 831-835. DOI: 10.13213/j.cnki.jeom.2019.19293
WANG Jin, WANG Ying, LI Pei-shuai, QIN Meng, JIANG Shou-fang, TONG Jun-wang. Effect of CYP11B2 gene polymorphism on susceptibility to essential hypertension in steel workers exposed to high temperature[J]. Journal of Environmental and Occupational Medicine, 2019, 36(9): 831-835. DOI: 10.13213/j.cnki.jeom.2019.19293
Citation: WANG Jin, WANG Ying, LI Pei-shuai, QIN Meng, JIANG Shou-fang, TONG Jun-wang. Effect of CYP11B2 gene polymorphism on susceptibility to essential hypertension in steel workers exposed to high temperature[J]. Journal of Environmental and Occupational Medicine, 2019, 36(9): 831-835. DOI: 10.13213/j.cnki.jeom.2019.19293

CYP11B2基因多态性对高温作业钢铁工人原发性高血压易感性的影响

Effect of CYP11B2 gene polymorphism on susceptibility to essential hypertension in steel workers exposed to high temperature

  • 摘要: 背景 原发性高血压(essental hypertension,EH)的发病由多种遗传和环境因素共同决定。在遗传因素中,CYP11B2基因-344T/C多态性的研究较多,高温作为职业危险因素,二者有可能交互作用于EH。

    目的 探讨CYP11B2基因-344T/C多态性和高温作业的交互作用对钢铁工人EH易感性的影响。

    方法 选择793名钢铁企业男性工人进行病例对照研究,包括EH组284例和对照组509例。对研究对象开展职业流行病学调查,采集静脉血。检测工作场所高温与噪声暴露情况。采用聚合酶链反应-限制性片段长度多态性检测工人CYP11B2基因-344T/C的多态性。采用多因素logistic回归和叉生分析方法分析CYP11B2基因-344T/C多态性与高温作业的相乘及相加交互作用对男性钢铁工人EH易感性的影响。

    结果 等位基因分析中,携带C等位基因工人患EH的危险性是携带T等位基因者的1.39倍(95% CI:1.09~1.77)。多因素logistc回归显示,高温作业者患EH的危险性是非高温作业者的1.43倍(95% CI:1.03~2.00),携带CC基因型工人患EH的危险性是TT型的2.48倍(95% CI:1.38~4.47)。高温和CYP11B2基因-344T/C多态性未显示出对于EH的相加交互作用(U=-0.258,P>0.05)与相乘交互作用(CC基因型OR=2.77,95% CI:0.97~7.88)。

    结论 CYP11B2基因-344T/C多态性中CC基因型可能是患EH的易感基因,在与EH的分析中,未发现其基因多态性与高温作业存在相加或相乘的交互作用。

     

    Abstract: Background The onset of essental hypertension (EH) is determined by a combinaton of genetc and environmental factors. Among the genetc factors, CYP11B2 gene-344T/C polymorphism is frequently studied. High temperature as an occupatonal risk factor and the polymorphism may have an interacton effect on EH.

    Objectve This study investgates the effect of the interacton between CYP11B2 gene-344T/C polymorphism and high temperature exposure on the susceptbility of steel workers to EH.

    Methods A case-control study was conducted among 793 male workers in an iron and steel enterprises, including 284 EH patents and 509 controls. An occupatonal epidemiological survey was conducted and venous blood samples were collected. High temperature and noise exposure in workplace were detected. CYP11B2 gene-344T/C polymorphism was detected by polymerase chain reacton-restricton fragment length polymorphism analysis. Multple logistc regression and fork analysis were used to analyze the additve and multplying effects of CYP11B2 gene-344T/C polymorphism and high temperature operaton on the susceptbility of male steel workers to EH.

    Results In the allelic analysis, the risk of developing EH in C allele carriers was 1.39 tmes that in T allele carriers (95%CI:1.09-1.77). The multple logistc regression results showed that the risk of developing EH in workers with high temperature operaton was 1.43 tmes that in workers without (95%CI:1.03-2.00), and the risk in workers carrying CC genotype was 2.48 tmes that in workers carrying TT genotype (95%CI:1.38-4.47). High temperature and CYP11B2 gene-344T/C polymorphism did not show additve interacton (U=-0.258, P>0.05) or multplicaton interacton (CC genotype OR=2.77, 95%CI:0.97-7.88) for EH.

    Conclusion The CC genotype of CYP11B2 gene-344T/C polymorphism is associated with elevated EH susceptibility. No additive or multplicaton interacton between its gene polymorphism and high temperature operaton is found.

     

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