杨秋月, 王海椒. 木粉尘职业暴露与肺癌关系病例对照研究的Meta分析[J]. 环境与职业医学, 2018, 35(3): 266-271. DOI: 10.13213/j.cnki.jeom.2018.17522
引用本文: 杨秋月, 王海椒. 木粉尘职业暴露与肺癌关系病例对照研究的Meta分析[J]. 环境与职业医学, 2018, 35(3): 266-271. DOI: 10.13213/j.cnki.jeom.2018.17522
YANG Qiu-yue, WANG Hai-jiao. Meta analysis of case-control studies on relationship between occupational exposure to wood dust and lung cancer[J]. Journal of Environmental and Occupational Medicine, 2018, 35(3): 266-271. DOI: 10.13213/j.cnki.jeom.2018.17522
Citation: YANG Qiu-yue, WANG Hai-jiao. Meta analysis of case-control studies on relationship between occupational exposure to wood dust and lung cancer[J]. Journal of Environmental and Occupational Medicine, 2018, 35(3): 266-271. DOI: 10.13213/j.cnki.jeom.2018.17522

木粉尘职业暴露与肺癌关系病例对照研究的Meta分析

Meta analysis of case-control studies on relationship between occupational exposure to wood dust and lung cancer

  • 摘要: 目的 探讨木粉尘职业暴露与肺癌的关系。

    方法 检索中国期刊全文数据库(CNKI)、中国科技期刊全文数据库(VIP)、万方数据库、Pubmed、Science Direct、WileyOnline Library、Web of Science、Google Scholar等,主题词包括“木粉尘”“木尘”“硬木尘”“软木尘”“木屑”“肺癌”“肺肿瘤”“wood dust” “hardwood dust” “softwood dust” “saw dust” “lung cancer” “lung carcinoma” “lung malignancy”,按照入选和排除标准筛选文献,采用Stata 12.0软件,用I 2统计量进行异质性检验,利用固定效应模型合并效应值,用Egger法检验发表性偏倚。

    结果 共纳入17篇关于职业性接触木粉尘与肺癌关联的病例对照研究文献。木粉尘职业暴露与肺癌发生有关联,发生风险增高,未校正混杂因素的合并OR=1.61(95% CI:1.46~1.78),调整后合并OR=1.49(95% CI:1.33~1.65)。木粉尘职业暴露引起其他类型肺癌的发生风险最高OR=1.48(95% CI:1.19~1.84),其次为鳞癌OR=1.43(95% CI:1.16~1.75)和腺癌OR=1.29(95% CI:1.06~1.57)。漏斗图和Egger法均显示本研究可能不存在发表偏倚。

    结论 木粉尘职业暴露可能增加肺癌发生风险。

     

    Abstract: Objective To assess the relationship between occupational exposure to wood dust and lung cancer.

    Methods Studies were identified through CNKI, VIP, Wanfang data, Pubmed, Science Direct, Wiley Online Library, Web of Science and Google Scholar, and the theme words included "wood dust, " "hardwood dust, " "softwood dust, " "saw dust, " "lung cancer, " "lung carcinoma, " and "lung malignancy, " in both Chinese and English. Studies were included according to inclusion and exclusion criteria. Heterogeneity test, combined effect value, and publication bias were carried out with I 2 statistics, fixed effect model, and Egger test method using Stata 12.0 software respectively.

    Results Seventeen papers reporting occupational exposure to wood dust and lung cancer were included. An increased risk of lu ng cancer was associated with occupational exposure to wood dust (unadjusted OR=1.61, 95%CI:1.46-1.78; adjusted OR=1.49, 95%CI:1.33-1.65). The highest risk of occupational exposure to wood dust was found in the category of other lung cancer (OR=1.48, 95%CI:1.19-1.84), followed by squamous cell carcinoma (OR=1.43, 95%CI:1.16-1.75), and adenocarcinoma (OR=1.29, 95%CI:1.06-1.57). The Funnel plot and Egger test results showed no publication bias in this study.

    Conclusion Occupational exposure to wood dust might increase the risk of lung cancer.

     

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