梁小滨, 朱若凯, 时庆华, 陈雯静, 容开萍, 汤昌海. 活性炭联合营养干预治疗儿童铅中毒的疗效观察[J]. 环境与职业医学, 2017, 34(9): 808-811. DOI: 10.13213/j.cnki.jeom.2017.17212
引用本文: 梁小滨, 朱若凯, 时庆华, 陈雯静, 容开萍, 汤昌海. 活性炭联合营养干预治疗儿童铅中毒的疗效观察[J]. 环境与职业医学, 2017, 34(9): 808-811. DOI: 10.13213/j.cnki.jeom.2017.17212
LIANG Xiao-bin, ZHU Ruo-kai, SHI Qing-hua, CHEN Wen-jing, RONG Kai-ping, TANG Chang-hai. Observation of curative effect on active carbon combined with nutritional intervention against lead poisoning in children[J]. Journal of Environmental and Occupational Medicine, 2017, 34(9): 808-811. DOI: 10.13213/j.cnki.jeom.2017.17212
Citation: LIANG Xiao-bin, ZHU Ruo-kai, SHI Qing-hua, CHEN Wen-jing, RONG Kai-ping, TANG Chang-hai. Observation of curative effect on active carbon combined with nutritional intervention against lead poisoning in children[J]. Journal of Environmental and Occupational Medicine, 2017, 34(9): 808-811. DOI: 10.13213/j.cnki.jeom.2017.17212

活性炭联合营养干预治疗儿童铅中毒的疗效观察

Observation of curative effect on active carbon combined with nutritional intervention against lead poisoning in children

  • 摘要: 目的 探讨活性炭联合营养干预对儿童铅中毒的治疗效果。

    方法 选择在某院门诊就诊的儿童铅中毒病例(血铅水平在100~249μg/L范围内,未进行过药物驱铅治疗)77人,按就诊顺序随机分为联合治疗组(39人)和常规治疗组(38人)。常规治疗组给予常规营养干预(钙250 mg/d、锌10 mg/d、维生素C 200 mg/d、维生素B15 mg/d,每日睡前一次口服);联合治疗组在常规治疗组治疗基础上加用活性炭片0.9 g/次,餐前口服,3次/日。连续干预治疗30 d,观察两组治疗结束时、治疗结束后第30天的血铅水平。

    结果 治疗结束时,联合治疗组儿童血铅水平降至正常范围(98.13μg/L),低于常规治疗组118.10μg/L(P < 0.05);治愈25例,治愈率为64.1%,明显高于常规治疗组的28.9%(P < 0.01)。治疗结束后第30天,联合治疗组血铅水平持续下降至68.75μg/L,而常规治疗组下降趋势明显变缓,降至108.77μg/L;2组治愈率分别为82.1%和42.1%。

    结论 活性炭联合营养干预可明显降低铅中毒儿童的血铅水平。

     

    Abstract: Objective To explore the curative effect of active carbon combined with nutritional intervention against lead poisoning in children.

    Methods A total of 77 lead poisoning children visiting the selected outpatient department in a hospital, whose blood lead le vels were in the range of 100-249 μg/L and who did not receive lead expelling drugs, were randomly divided into a combined treatment group (n=39) and a traditional treatment group (n=38). The traditional treatment group was given routine nutritional in tervention (calcium 250 mg/d, zinc 10 mg/d, vitamin C 200 mg/d, and vitamin B1 5 mg/d, oral administration once daily at bedtime); the combined treatment group was additionally given activated carbon tablet 0.9 g/time before meal, 3 times/d. After continuous in tervention treatment for 30 d, the blood lead levels of the two groups were observed at the end of treatment and 30 d later.

    Results At the end of treatment, the combined treatment group's average blood lead level dropped to normal range (98.13μg/L), low er than that of the traditional treatment group (118.10 μg/L) (P < 0.05). Twenty-five cases were cured with a cure rate of 64.1% in the combined treatment group, higher than that of the traditional treatment group (28.9%) (P < 0.01). On the 30th day after the treatment, the average blood lead level of the combined treatment group continued to drop to 68.75μg/L, while that of the traditional treatment group dropped to 108.77 μg/L with a decrease trend slowing down obviously; the cure rates of the two groups were 82.1% and 42.1%, respectively.

    Conclusion Active carbon combined with nutritional intervention can significantly reduce blood lead level in children with le ad poisoning.

     

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