黄振, 汪一心, 鲁文清. 男性精浆17种金属浓度与血清生殖激素水平的关系[J]. 环境与职业医学, 2017, 34(4): 297-303. DOI: 10.13213/j.cnki.jeom.2017.16755
引用本文: 黄振, 汪一心, 鲁文清. 男性精浆17种金属浓度与血清生殖激素水平的关系[J]. 环境与职业医学, 2017, 34(4): 297-303. DOI: 10.13213/j.cnki.jeom.2017.16755
HUANG Zhen, WANG Yi-xin, LU Wen-qinq. Relationships between 17 metal concentrations in seminal plasma and serum reproductive hormone levels in men[J]. Journal of Environmental and Occupational Medicine, 2017, 34(4): 297-303. DOI: 10.13213/j.cnki.jeom.2017.16755
Citation: HUANG Zhen, WANG Yi-xin, LU Wen-qinq. Relationships between 17 metal concentrations in seminal plasma and serum reproductive hormone levels in men[J]. Journal of Environmental and Occupational Medicine, 2017, 34(4): 297-303. DOI: 10.13213/j.cnki.jeom.2017.16755

男性精浆17种金属浓度与血清生殖激素水平的关系

Relationships between 17 metal concentrations in seminal plasma and serum reproductive hormone levels in men

  • 摘要: 目的 探讨男性精浆金属浓度与血清生殖激素水平之间的关系。

    方法 选择2013年3月至6月到武汉市某生殖医学中心就诊的746名男性进行问卷调查,并测定其精浆中17种金属的含量,采用多元线性回归分析精浆金属浓度和血清生殖激素水平的关系(n=378)。

    结果 多变量线性回归分析显示,与精浆钴、硒和铊浓度处于<P25组的男性相比较,钴、硒和铊浓度处于>P75组的男性精浆钴、硒和铊与卵泡刺激素呈正相关(b=18.50,95%CI:2.00~36.00;b=17.40,95%CI:0.80~35.00;b=18.50,95%CI:3.40~37.70)。与精浆钼浓度处于<P25组的男性相比较,钼浓度处于>P75组的男性精浆钼与黄体生成素呈正相关(b=12.50,95%CI:0.10~27.00);与精浆铬浓度处于<P50组的男性相比较,铬浓度处于>P75组的男性精浆铬与黄体生成素呈建议性的负相关(b=-0.90,95%CI:-22.00~1.50)。与精浆镉、钴、锌和钼浓度处于<P25组的男性相比较,镉、钴、锌和钼浓度处于>P75组的男性精浆镉、钴、锌和钼与性激素结合球蛋白呈正相关或建议性的正相关(b=18.00,95%CI:5.10~36.00;b=16.20,95%CI:4.00~31.00;b=7.80,95%CI:-4.00~21.00;b=13.00,95%CI:0.40~27.00)。与精浆锡浓度处于<P60组的男性相比较,锡浓度处于>P80组男性精浆锡与睾酮呈建议性的负相关(b=-7.30,95%CI:-17.40~2.00)。

    结论 环境钴、硒、铊、钼、铬、镉、锌和锡暴露可能与男性血清生殖激素水平的改变有关。

     

    Abstract: Objective To assess the associations between metal concentrations in seminal plasma and serum reproductive hormone levels in men.

    Methods A total of 746 men visiting a reproductive center in Wuhan between March and June 2013 were chosen to conduct a survey with questionnaire and laboratory test on seventeen metals in seminal plasma. Multiple linear regression models were utilized to assess the associations between the concentrations of seminal plasma metals and the levels of serum reproductive hormones (n=378).

    Results The results of multiple linear regression models showed that the cobalt, selenium, and thallium in seminal plasma of the >P75group were positively associated with follicle-stimulating hormone (b=18.50, 95%CI: 2.00-36.00;b=17.40, 95%CI: 0.80-35.00;b=18.50, 95%CI: 3.40-37.70) compared with those of the<P25group respectively. The molybdenum in seminal plasma of the >P75group was positively associated with luteinizing hormone (b=12.50, 95%CI: 0.10-27.00) compared with that of the<P25group. The chromium in seminal plasma of the >P75group was suggestively inversely associated with luteinizing hormone (b=-0.90, 95%CI:-22.00-1.50) compared with that of the<P50group. The cadmium, cobalt, zinc, and molybdenum in seminal plasma of the >P75group were positively or suggestively positively associated with sex hormone-binding globulin (b=18.00, 95%CI: 5.10-36.00;b=16.20, 95%CI: 4.00-31.00;b=7.80, 95%CI:-4.00-21.00;b=13.00, 95%CI: 0.40-27.00) compared with those of the<P25group. The tin in seminal plasma of the >P80group was suggestively inversely associated with testosterone (b=-7.30, 95%CI:-17.40-2.00) compared with that of the<P60group.

    Conclusion Environmental exposure to cobalt, selenium, thallium, molybdenum, chromium, cadmium, zinc, and tin may be associated with alteration of serum reproductive hormone levels in men.

     

/

返回文章
返回