郭佳林, 高曦, 陈婧司, 刘颖钏, 孙静, 贲晓明, 吴岷, 厉曙光, 陈波. 新生儿胎粪中邻苯二甲酸酯代谢物与脐带血激素水平的关联[J]. 环境与职业医学, 2017, 34(4): 291-296. DOI: 10.13213/j.cnki.jeom.2017.16701
引用本文: 郭佳林, 高曦, 陈婧司, 刘颖钏, 孙静, 贲晓明, 吴岷, 厉曙光, 陈波. 新生儿胎粪中邻苯二甲酸酯代谢物与脐带血激素水平的关联[J]. 环境与职业医学, 2017, 34(4): 291-296. DOI: 10.13213/j.cnki.jeom.2017.16701
GUO Jia-lin, GAO Xi, CHEN Jing-si, LIU Ying-chuan, SUN Jing, BEN Xiao-ming, WU Min, LI Shu-guang, CHEN Bo. Phthalate metabolites in meconium and their associations with hormones in cord blood[J]. Journal of Environmental and Occupational Medicine, 2017, 34(4): 291-296. DOI: 10.13213/j.cnki.jeom.2017.16701
Citation: GUO Jia-lin, GAO Xi, CHEN Jing-si, LIU Ying-chuan, SUN Jing, BEN Xiao-ming, WU Min, LI Shu-guang, CHEN Bo. Phthalate metabolites in meconium and their associations with hormones in cord blood[J]. Journal of Environmental and Occupational Medicine, 2017, 34(4): 291-296. DOI: 10.13213/j.cnki.jeom.2017.16701

新生儿胎粪中邻苯二甲酸酯代谢物与脐带血激素水平的关联

Phthalate metabolites in meconium and their associations with hormones in cord blood

  • 摘要: 目的 了解新生儿邻苯二甲酸酯(PAEs)宫内暴露的质量浓度(后称“浓度”),并探索其与新生儿性激素或甲状腺激素水平的关联。

    方法 收集新生儿胎粪并检测胎粪中常见PAEs的代谢物,收集脐带血并检测游离睾酮(FT)、总四碘甲状腺素(T4)等常见性激素指标和甲状腺激素指标,并采用线性回归方法分析两者间的关系。

    结果 新生儿胎粪中检出的代谢物主要是邻苯二甲酸单乙基己酯(MEHP)、邻苯二甲酸单正丁酯(MnBP)和邻苯二甲酸单异丁酯(MiBP),检出率分别为100%、99%和99%。男性新生儿雌二醇(E2)水平与邻苯二甲酸单甲酯(MMP)(b=2.44,P=0.027)、MnBP(b=4.08,P=0.044)及MiBP(b=3.89,P=0.003)呈正相关,FT与MEHP(b=4.42,P=0.049)呈正相关;女性新生儿性激素水平与各PAEs代谢物浓度未见关联。除男性促甲状腺激素(TSH)与邻苯二甲酸单乙酯(MEP)浓度(b=0.40,P=0.015)呈正相关外,新生儿甲状腺激素其余指标与PAEs浓度均未见关联。

    结论 新生儿宫内暴露于PAEs与新生儿的性激素水平变化可能存在一定的关联。

     

    Abstract: Objective To understand the fetal exposure concentrations to phthalic acid esters (PAEs) and assess the associations between PAEs concentrations and the levels of sex hormones or thyroid hormones in newborns.

    Methods Linear regression models were used to assess the associations between PAEs metabolites in meconium samples and sex or thyroid hormones free testosterone (FT) and total thyroxine (T4) in cord blood samples.

    Results The main metabolites in meconium were mono-2-ethylhexyl phthalate (MEHP), mono-n-butyl phthalate (MnBP), and monoisobutyl phthalate (MiBP), with detection rates of 100%, 99%, and 99%, respectively. Estradiol level in newborn boys was positively correlated to the concentrations monomethyl phthalate (MMP) (b=2.44, P=0.027), MnBP (b=4.08, P=0.044), and MiBP (b=3.89, P=0.003). FT in newborn boys was positively correlated to MEHP (b=4.42, P=0.049). None of PAEs metabolite concentrations was related to sex hormone level in newborn girls. Thyroid stimulating hormone (TSH) level in newborn boys was positively correlated to MEP concentration (b=0.40, P=0.015). No other associations between thyroid hormone levels and PAEs metabolite concentrations in meconium were found.

    Conclusion Fetal exposure to PAEs may be associated with changes of sex hormone levels in newborns.

     

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