佟俊旺, 王颖, 田璐, 金曼. 中国汉族人群血管紧张素转换酶基因多态性与原发性高血压关系的Meta分析[J]. 环境与职业医学, 2017, 34(2): 118-123. DOI: 10.13213/j.cnki.jeom.2017.16578
引用本文: 佟俊旺, 王颖, 田璐, 金曼. 中国汉族人群血管紧张素转换酶基因多态性与原发性高血压关系的Meta分析[J]. 环境与职业医学, 2017, 34(2): 118-123. DOI: 10.13213/j.cnki.jeom.2017.16578
TONG Jun-wang, WANG Ying, TIAN Lu, JIN Man. Meta-analysis on association between polymorphism of angiotensin converting enzyme and essential hypertension in Han ethnic group in China[J]. Journal of Environmental and Occupational Medicine, 2017, 34(2): 118-123. DOI: 10.13213/j.cnki.jeom.2017.16578
Citation: TONG Jun-wang, WANG Ying, TIAN Lu, JIN Man. Meta-analysis on association between polymorphism of angiotensin converting enzyme and essential hypertension in Han ethnic group in China[J]. Journal of Environmental and Occupational Medicine, 2017, 34(2): 118-123. DOI: 10.13213/j.cnki.jeom.2017.16578

中国汉族人群血管紧张素转换酶基因多态性与原发性高血压关系的Meta分析

Meta-analysis on association between polymorphism of angiotensin converting enzyme and essential hypertension in Han ethnic group in China

  • 摘要: 目的 探究我国汉族人群血管紧张素转换酶(ACE)基因插入/缺失(I/D)多态性与原发性高血压(EH)之间的关系。

    方法 收集国内外2000年1月-2016年1月间发表的关于我国汉族人群ACE基因I/D多态性与EH关系的文献29篇,共计5 485例原发性高血压患者,4 878例健康对照。提取病例组与对照组基因型及等位基因的分布数据,应用Stata 12.0软件,利用随机效应或固定效应模型合并效应值,并对结果进行发表偏倚的检验。

    结果 基因型相比,ID基因型患高血压OR=1.05(95% CI:0.92~1.19),DD基因型患高血压OR=1.66(95% CI:1.34~2.05)。与I等位基因相比,D等位基因患高血压合并OR=1.25(95% CI:1.12~1.40)。漏斗图、Egger法检验以及失安全系数等结果均表明此次Meta分析存在发表偏倚的可能性较小。

    结论 我国汉族人群携带DD基因型及D等位基因者能增加EH发病风险。

     

    Abstract: Objective To study the relationship between polymorphism of angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) genotype and essential hypertension (EH) in Han ethnic group in China.

    Methods Twenty-nine eligible papers reported the association between polymorphism of ACE gene and EH patients in Han ethnic group in China from January 2000 to January 2016, which included 5 485 cases and 4 878 healthy controls. The data of case and control groups' genotypes and alleles were extracted. Combined effect values were derived by fixed or random effect model and used to test and adjust publication bias using Stata 12.0 software.

    Results The pooled OR for ID genotype and DD genotype versus II genotype were 1.05 (95%CI:0.92-1.19) and 1.66 (95%CI:1.34-2.05), respectively. The pooled OR for D allele versus I allele was 1.25 (95%CI:1.12-1.40). The results of funnel plot, Egger's test, and fail-safe number showed minor publication bias in the present meta-analysis.

    Conclusion Bearing DD genotype and D allele of ACE gene may associate with a higher risk of EH in Han ethnic group in China.

     

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