钨及其合金健康影响的研究进展

Progress on health effects of tungsten and its alloys

摘要: 钨及其合金的主要成分包括钨、钴和碳化钨，是制造硬质合金的主要原料。本文介绍了钨及其合金的接触水平及主要健康影响，总结了钨及其合金的剂量反应关系和遗传易感性研究结果，认为钨及其合金的外接触剂量与内接触剂量（如尿、血等生物样本）或某些生物标志存在一定的相关性，但其健康影响具有一定的个体差异。在我国进行钨及其合金的健康影响评估研究，是防治新增法定职业病--硬金属肺病的迫切需求。

Abstract: The main compositions of tungsten and its alloys include tungsten, cobalt, and tungsten carbide, which are the raw materials of hard alloys. This paper introduced the exposure levels and major health effects of tungsten and its alloys, and summarized research results on related dose-response relationship and genetic susceptibility. It could be concluded that there were relationships between external exposure dose and internal exposure dose (such as urine or blood sample) or between external exposure dose and selected biomarkers. Meanwhile, individual variance also played an important role in the health effects of tungsten and its alloys. It is urgent to conduct health impact assessment research on tungsten and its alloys in order to control a new statutory occupational disease, hard metal lung disease, in China.