章群, 闫鹏. 电离辐射的DNA甲基化调控机制及生物学效应[J]. 环境与职业医学, 2016, 33(9): 911-914. DOI: 10.13213/j.cnki.jeom.2016.16191
引用本文: 章群, 闫鹏. 电离辐射的DNA甲基化调控机制及生物学效应[J]. 环境与职业医学, 2016, 33(9): 911-914. DOI: 10.13213/j.cnki.jeom.2016.16191
ZHANG Qun, YAN Peng. DNA Methylation Regulation Mechanism and Biological Effects of Ionizing Radiation[J]. Journal of Environmental and Occupational Medicine, 2016, 33(9): 911-914. DOI: 10.13213/j.cnki.jeom.2016.16191
Citation: ZHANG Qun, YAN Peng. DNA Methylation Regulation Mechanism and Biological Effects of Ionizing Radiation[J]. Journal of Environmental and Occupational Medicine, 2016, 33(9): 911-914. DOI: 10.13213/j.cnki.jeom.2016.16191

电离辐射的DNA甲基化调控机制及生物学效应

DNA Methylation Regulation Mechanism and Biological Effects of Ionizing Radiation

  • 摘要:

    DNA甲基化在生物学过程中作用重要,机体处于甲基化平衡状态是基因表达的合理调控及遗传物质保持稳定等生命活动的必要保障。电离辐射可导致全基因组低甲基化和CpG岛启动子区部分基因的高甲基化,是肿瘤、衰老及免疫功能下降的诱因之一。本文综述电离辐射致机体DNA甲基化状态的改变,电离辐射致DNA甲基化异常的生物学效应及其作用机制,并提出干预电离辐射致机体甲基化失衡的一些设想。

     

    Abstract:

    DNA methylation plays an important role in biological processes. Balance of methylation warrants life activities such as regulation of appropriate gene expression and stability maintenance of genetic materials. Ionizing radiation can induce hypomethylation in whole genome and hypermethylation in part of genes in CpG islands, which is a potential trigger of cancer, aging, and decreased immune function. In this paper, we described the changes and the biological effects and possible mechanisms of ionizing radiation-induced DNA methylation abnormality, and also proposed some opinions to prevent ionizing radiation-induced methylation imbalance.

     

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