郭小燕, 郭掌珍. 非职业暴露人群血清有机氯农药蓄积水平研究[J]. 环境与职业医学, 2015, 32(10): 953-955,959. DOI: 10.13213/j.cnki.jeom.2015.15106
引用本文: 郭小燕, 郭掌珍. 非职业暴露人群血清有机氯农药蓄积水平研究[J]. 环境与职业医学, 2015, 32(10): 953-955,959. DOI: 10.13213/j.cnki.jeom.2015.15106
GUO Xiao-yan , GUO Zhang-zhen . Accumulative Levels of Organochlorine Pesticides in Serum of Non-Occupationally Exposed Population[J]. Journal of Environmental and Occupational Medicine, 2015, 32(10): 953-955,959. DOI: 10.13213/j.cnki.jeom.2015.15106
Citation: GUO Xiao-yan , GUO Zhang-zhen . Accumulative Levels of Organochlorine Pesticides in Serum of Non-Occupationally Exposed Population[J]. Journal of Environmental and Occupational Medicine, 2015, 32(10): 953-955,959. DOI: 10.13213/j.cnki.jeom.2015.15106

非职业暴露人群血清有机氯农药蓄积水平研究

Accumulative Levels of Organochlorine Pesticides in Serum of Non-Occupationally Exposed Population

  • 摘要: 目的 了解山西省范围内非职业暴露人群血清中有机氯农药(OCPs)的蓄积水平。

    方法 本研究选取21~65 岁山西籍、无农药暴露史的360 名男性和240 名女性, 收集其血清样品, 用气相色谱电子捕获检测器(GC-ECD)测定血清中21 种OCPs 的蓄积水平, 并采用Spearman 方法对血清OCPs 含量与血脂和体质指数(BMI)的相关性进行检验。

    结果 山西省范围内非职业暴露人群男性血清中以下6 种有机氯农药蓄积量M(P25~P75), 包括γ-HCH42.38(32.65~52.64)ng/g 脂肪重量、艾氏剂65.55(51.26~83.29)ng/g 脂肪重量、七氯62.57(38.73~157.87)ng/g 脂肪重量、七氯环氧化物32.75(ND~49.34)ng/g 脂肪重量、硫丹硫酸盐53.96(28.20~134.14)ng/g 脂肪重量、狄氏剂19.60(ND~31.50)ng/g 脂肪重量高于女性(P < 0.05 或P < 0.01)。人群血清OCPs 与BMI 之间的相关性较差, 但六六六(HCHs)、O, P'-DDT、艾氏剂与血脂含量均表现出显著相关关系(P < 0.05 或P < 0.01)。

    结论 OCPs 在山西省范围内人群中有一定蓄积, 其含量与性别、血脂含量有一定的相关性。

     

    Abstract: Objective To measure the concentrations of organochlorine pesticides (OCPs) accumulated in the serum of non-occupationally exposed population in Shanxi Province.

    Methods Blood samples were collected from 360 males and 240 females between 21-65 years old with no pesticide exposure history from Shanxi Province. Gas chromatography electron capture detector (GC-ECD) was used to quantify the accumulative concentrations of 21 OCPs in serum. Spearman's rank was performed to determine the correlations between accumulated OCPs concentrations and blood lipid or body mass index (BMI).

    Results Higher levels M (P25~P75) in males of γ-HCH 42.38 (32.65~52.64) ng/g fat mass, aldrin 65.55 (51.26~83.29) ng/g fat mass, heptachlor 62.57 (38.73~157.87) ng/g fat mass, heptachlor epoxide 32.75 (ND~49.34) ng/g fat mass, endosulfan sulfate 53.96 (28.20~134.14) ng/g fat mass, and dieldrin 19.60 (ND~31.50) ng/g fat mass were found versus females (P < 0.05 or P < 0.01). There was a positive correlation between the serum concentrations of HCHs, O, P'-DDT, aldrin and blood lipid (P < 0.05 or P < 0.01), but no significant difference was found between serum OCPs and BMI.

    Conclusion The OCPs have a certain accumulation in the investigated population, and the concentrations are associated with gender and blood lipid.

     

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