Abstract: Parkinson's disease is a common central nervous system degenerative disease, characterized by the loss of dopaminergic neuron in the substantia nigra and striatum of midbrain, which can be induced by various factors. The current paper sketches about environmental and occupational risk factors of Parkinson's disease and the latest progress of the induced pluripotent stem cells (iPScs) technology, analyses the application prospects of iPScs in the pathogenesis research of Parkinson's disease in duced by environmental and occupational risk factors, and proposes its potential significance in this area.