尚孟晴, 朱贝贝, 陶芳标. 空气污染与围生期抑郁关系的研究进展[J]. 环境与职业医学, 2022, 39(10): 1180-1186. DOI: 10.11836/JEOM22168
引用本文: 尚孟晴, 朱贝贝, 陶芳标. 空气污染与围生期抑郁关系的研究进展[J]. 环境与职业医学, 2022, 39(10): 1180-1186. DOI: 10.11836/JEOM22168
SHANG Mengqing, ZHU Beibei, TAO Fangbiao. A review of progress in research of relationship between air pollution and perinatal depression[J]. Journal of Environmental and Occupational Medicine, 2022, 39(10): 1180-1186. DOI: 10.11836/JEOM22168
Citation: SHANG Mengqing, ZHU Beibei, TAO Fangbiao. A review of progress in research of relationship between air pollution and perinatal depression[J]. Journal of Environmental and Occupational Medicine, 2022, 39(10): 1180-1186. DOI: 10.11836/JEOM22168

空气污染与围生期抑郁关系的研究进展

A review of progress in research of relationship between air pollution and perinatal depression

  • 摘要:

    近年来围生期抑郁(PND)发生率持续上升,已经成为重要的公共卫生问题,除了传统的社会人口学因素、生物学因素、产科因素等,空气污染与PND的关联也越来越受到人们的关注。本文回顾了近年来国内外有关空气污染和PND关联的流行病学研究,重点讨论了室外空气污染物如PM2.5、PM10、NO2和O3等和室内空气污染物如烟草烟雾与PND的关联,归纳了不同污染物对PND影响的特点和可能的生物学机制。基于目前的研究,多种室外空气污染物都与PND存在关联,且某些污染物与之可能存在剂量-反应关系。而针对室内空气污染,目前研究只关注了烟草暴露对PND的影响,尚无研究探索其他的室内污染物如油烟、固体燃料等与PND的关联。目前研究显示空气污染可能通过氧化应激、神经内分泌机制作用于与PND,但确切生物机制仍有待进一步研究。未来应该进一步加强室内其他空气污染物与PND的流行病学关联研究及空气污染与其他因素的交互作用对PND影响及相关的生物学机制研究,从而为从环境健康角度上预防PND提供新思路。

     

    Abstract:

    In recent years, the increasing incidence of perinatal depression has become an important public health problem. In addition to the traditional social demographic factors, biological factors, obstetric factors, etc., the association between air pollution and perinatal depression (PND) has also attracted more and more attention. In this paper, studies on the association between air pollution and PND were reviewed, especially the associations of PND with ambient air pollutants such as PM2.5, PM10, NO2, and O3 as well as indoor air pollutants such as tobacco smoke, and the characteristics and possible biological mechanisms of the influence of different pollutants on PND were summarized. Based on the available studies, various outdoor air pollutants are associated with PND, and some pollutants may exhibit a dose-response relationship with it. As for indoor air pollution, studies only have focused on the impact of tobacco exposure on PND, and as yet, no study has explored the association between other indoor pollutants (e.g. cooking oil smoke and solid fuel) and PND. Current studies indicate that air pollution may act on PND through oxidative stress and neuroendocrine mechanisms, but the exact biological mechanism remains to be further studied. In the future, further studies should be encouraged on the epidemiological associations of other indoor air pollutants with PND and the interactions between other factors and air pollution on PND, and the underlying biological mechanisms, to provide new insights for the prevention of PND from the perspective of environmental health.

     

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