杨钰坪, 陈卿, 张莉雯, 韩珊珊, 周妮娅, 徐琰, 明佳. 昼夜节律与甲状腺功能及疾病的关系研究进展[J]. 环境与职业医学, 2022, 39(9): 1051-1056. DOI: 10.11836/JEOM22016
引用本文: 杨钰坪, 陈卿, 张莉雯, 韩珊珊, 周妮娅, 徐琰, 明佳. 昼夜节律与甲状腺功能及疾病的关系研究进展[J]. 环境与职业医学, 2022, 39(9): 1051-1056. DOI: 10.11836/JEOM22016
YANG Yuping, CHEN Qing, ZHANG Liwen, HAN Shanshan, ZHOU Niya, XU Yan, MING Jia. Research progress on relationships of circadian rhythm with thyroid function and diseases[J]. Journal of Environmental and Occupational Medicine, 2022, 39(9): 1051-1056. DOI: 10.11836/JEOM22016
Citation: YANG Yuping, CHEN Qing, ZHANG Liwen, HAN Shanshan, ZHOU Niya, XU Yan, MING Jia. Research progress on relationships of circadian rhythm with thyroid function and diseases[J]. Journal of Environmental and Occupational Medicine, 2022, 39(9): 1051-1056. DOI: 10.11836/JEOM22016

昼夜节律与甲状腺功能及疾病的关系研究进展

Research progress on relationships of circadian rhythm with thyroid function and diseases

  • 摘要:

    昼夜节律是生物钟基因的转录-翻译反馈环受外界环境条件影响而形成的生命活动昼夜周期性变化现象。昼夜节律系统控制着生物体内几乎所有的生理过程,这些过程会随着外界环境的变化而发生改变。既往研究显示哺乳动物中下丘脑-垂体-甲状腺轴受下丘脑视交叉上核中央昼夜节律起搏器的调控,故甲状腺部分功能受生物钟控制,血液中甲状腺激素的分泌能呈现出昼夜节律特征。但生物钟对甲状腺调控作用的分子机制尚不明确,昼夜节律干扰是否与甲状腺功能的紊乱和甲状腺疾病的发生有关值得关注。本文围绕生物钟和昼夜节律与甲状腺功能的研究进展,从甲状腺生理功能的昼夜节律特性以及睡眠剥夺、夜间光照、夜班轮班对甲状腺功能的影响方面,重点综述了昼夜节律紊乱与甲状腺功能和以甲状腺恶性肿瘤为代表的甲状腺疾病的关系。分析表明,昼夜节律紊乱可能扰乱甲状腺激素的节律性分泌,但对甲状腺疾病特别是甲状腺恶性肿瘤的影响尚无明确结论,有必要进一步加强相关流行病学和分子机制研究。

     

    Abstract:

    Circadian rhythm is a phenomenon of diurnal changes in life activities formed by a transcription-translation feedback loop of biological clock genes affected by external environmental conditions. The circadian rhythm system controls almost all physiological processes in the organism, and these processes will change as the external environment changes. Previous studies have shown that the hypothalamic-pituitary-thyroid axis in mammals is regulated by the central diurnal pacemaker of the suprachiasmatic nucleus of the hypothalamus, so part of the thyroid function is controlled by the biological clock, and the secretion of thyroid hormones in blood can present a circadian rhythm. However, the molecular mechanism of the biological clock's regulatory effect on thyroid is still unclear. Whether circadian rhythm interference is related to the disorder of thyroid function or the occurrence of thyroid diseases is worthy of attention. This paper focused on the research progress of biological clock, circadian rhythm, and thyroid function, specifically the characteristics of circadian rhythm of thyroid physiological function and the effects of sleep deprivation, light at night, and night shift work on thyroid function, elaborated the relationships of circadian rhythm disorder with thyroid function and thyroid diseases represented by thyroid malignant tumors. The review summarized that circadian rhythm disorder may disrupt the rhythmic secretion of thyroid hormones, but no clear conclusion is reached yet on any effect on thyroid diseases, especially thyroid malignant tumors, so it is necessary to further strengthen the relevant epidemiological and molecular mechanism research.

     

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