环状RNA与矽肺纤维化的研究进展
Research progress of circRNA in silicosis fibrosis
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摘要:
矽肺是一种慢性进行性肺部纤维化疾病，严重危害劳动者职业健康，目前尚无有效治疗措施，亟须寻找有效的治疗靶点，通过分子标志物来靶向干预矽肺纤维化进程。环状RNA（circRNA）作为一类新型的非编码RNA，具有结构稳定、半衰期长、高度保守性的特性，且在不同物种、组织、疾病和发育阶段特异性表达，作为生物标志物具有潜在价值和应用前景。近几年，circRNA在人类疾病发生发展中的调控作用已成为研究热点，部分circRNA被发现与矽肺纤维化发病的机制有关。本文简述了circRNA的生物学特性与功能，重点讨论已报道的circRNA与矽肺纤维化发病机制间的关系，总结当前circRNA介导矽肺纤维化发病机制的研究进展，进而提出深入研究靶向circRNA诊治矽肺纤维化的方向和建议。
Abstract: Silicosis is a chronic progressive pulmonary fibrosis disease that seriously endangers the occupational health of workers. There is no effective treatment at present. It is urgent to find effective therapeutic targets and use molecular markers to intervene the process of silicosis fibrosis. As a new type of non-coding RNA, circular RNA (circRNA) has the characteristics of stable structure, long half-life, high conservation, and is specifically expressed in different species, tissues, diseases, and developmental stages, and has potential value and application prospects as a biomarker. In recent years, the regulatory role of circRNA in the occurrence and development of human diseases has become a research hotspot. Some circRNAs have been found to associate with the pathogenesis of silicosis. This article briefly described the biological characteristics and functions of circRNA, focused on the reported relationship between circRNA and pathogenesis of silicosis, summarized the current research progress of circRNA-mediated pathogenesis of silicosis, and then put forward potential directions and suggestions for further research on targeting circRNA in the diagnosis and treatment of silicotic fibrosis.
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