WANG Jun, XU Ming, LIU Jing, WANG Xiu-xia, SHEN Huan-xi, CAI Wen-yan, HAN Lei, ZHANG Heng-dong, ZHU Bao-li. Association between XYLT1 SNPs and noise-induced hearing loss in Chinese Han occupational group[J]. Journal of Environmental and Occupational Medicine, 2018, 35(8): 741-749. DOI: 10.13213/j.cnki.jeom.2018.18204
Citation: WANG Jun, XU Ming, LIU Jing, WANG Xiu-xia, SHEN Huan-xi, CAI Wen-yan, HAN Lei, ZHANG Heng-dong, ZHU Bao-li. Association between XYLT1 SNPs and noise-induced hearing loss in Chinese Han occupational group[J]. Journal of Environmental and Occupational Medicine, 2018, 35(8): 741-749. DOI: 10.13213/j.cnki.jeom.2018.18204

Association between XYLT1 SNPs and noise-induced hearing loss in Chinese Han occupational group

  • Objective To investigate whether XYLT1 single nucleotide polymorphisms (SNPs) are associated with susceptibility to noiseinduced hearing loss (NIHL) in a Chinese Han occupational group.

    Methods A case-control study was performed among workers with exposure to noise in a textile mill and a large-scale power plant in Jiangsu province. A total of 1 956 workers received physical examination, questionnaire survey, and pure-tone audiometry. Those with an average hearing threshold ≥ 40 dB in high frequency were defined as NIHL cases (n=660), and the others as the controls (n=650). The noise intensity of the operation site and individual noise exposure level were measured with sound level meter and multifunctional noise dosimeter, respectively. The cumulative noise exposure (CNE) level was calulated. The genotypes of XYLT1 were determined by TaqMan assay. The distributions of mean values of age, working age, noise exposure level, CNE, and high frequency threshold between the two groups were analyzed by independent-sample t test; the distributions of age, gender, smoking, drinking, and other categorical variables between the two groups were analyzed by two-sided χ2 test; the association between XYLT1 SNPs and susceptibility to NIHL was assessed in a binary logistic regression model, and further stratified by CNE. Two-sided χ2 test was also performed for haplotype analysis.

    Results The overall noise exposure level detected in the 342 sites were 75.2-100.0 dB(A), and that in 223 workers were 68.5-108.1 dB(A). The NIHL case group showed longer average noise exposure time(227.6±94.8) months and a three-fold higher average high frequency hearing threshold(37.2±11.8) dB than the control group(218.1±88.4) months, (14.0±4.0) dB, as well as lower prevalence rates of ear disease among participants and their relatives (Ps < 0.05). After adjusting for age, sex, smoking, and drinking, rs7185607 A allele (OR=1.57, 95%CI:1.07-2.31), rs7205152 C allele (OR=1.63, 95%CI:1.12-2.37), rs7191414 A allele (OR=1.70, 95%CI:1.01-2.77), rs12598082 G allele (OR=1.76, 95%CI:1.27-2.44), and rs2311140 G allele (OR=1.85, 95%CI:1.34-2.55) increased the risk of presenting NIHL, while rs59385104 C allele (OR=0.51, 95%CI:0.27-0.96) decreased the risk (Ps < 0.05). When CNE > 100(dB·year), compared with rs7185607 CC genotype, the individuals carrying CA/AA genotype had an increased risk of presenting NIHL(OR=1.60, 95%CI:1.16-2.20); compared with rs7191414 TT genotype, those carrying AT/AA genotype had an increased risk of presenting NIHL(OR=2.21, 95% CI:1.47-3.32); compared with rs2311140 AA genotypes, those carrying GA/GG genotype had an increased risk of presenting NIHL(OR=1.93, 95%CI:1.39-2.71)(Ps < 0.05). When CNE ≤ 100(dB·year), compared with rs2311140AA genotype, carrying GA/GG genotype increased the risk of presenting NIHL(OR=2.42, 95%CI:1.72-3.41, P < 0.001). The results of dominant and recessive models showed that only rs2311140 G allele increased the risk of presenting NIHL in both models (OR=2.22, 95%CI:1.39-3.53; OR=2.08, 95%CI:1.17-3.68)(Ps < 0.05). According to the results of haplotype analysis, XYLT1 haplotype ATTA (OR=0.580, 95%CI:0.422-0.798) and haplotype CCTA (OR=0.496, 95%CI:0.355-0.693) were the protective factors of presenting NIHL (Ps < 0.05); haplotype CTTG was a risk factor of presenting NIHL (OR=1.724, 95%CI:1.450-2.049, P < 0.001).

    Conclusion XYLT1 may be a susceptible gene of NIHL. The rs2311140 G allele and haplotype rs7185607 C-rs7205152 T-rs7191414 T-rs12598082G of XYLT1 may be potential susceptible molecular markers of NIHL. The interaction between polymorphism and noise at rs7185607, rs7191414, and rs2311140 may have an important impact on NIHL.

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