ZHANG Jian-fen, WU Xiao-xia, WU Jun-mei, ZHANG Yuan-hai, YE Chun-jiang, NI Liang-fang. Efficacy and safety of arterial infusion of calcium gluconate in treating hydrofluoric acid burns of hand[J]. Journal of Environmental and Occupational Medicine, 2018, 35(8): 725-728. DOI: 10.13213/j.cnki.jeom.2018.18215
Citation: ZHANG Jian-fen, WU Xiao-xia, WU Jun-mei, ZHANG Yuan-hai, YE Chun-jiang, NI Liang-fang. Efficacy and safety of arterial infusion of calcium gluconate in treating hydrofluoric acid burns of hand[J]. Journal of Environmental and Occupational Medicine, 2018, 35(8): 725-728. DOI: 10.13213/j.cnki.jeom.2018.18215

Efficacy and safety of arterial infusion of calcium gluconate in treating hydrofluoric acid burns of hand

  • Objective To evaluate the efficacy and safety of arterial infusion of calcium gluconate (CG) in the treatment of hydrofluoric acid burns of hand.

    Methods From January 2010 to December 2017, a total of 47 patients with hydrofluoric acid burns of hand met inclusion criteria. An indwelling needle was placed on the radial artery of the affected limb. They were injected with 10% CG (15 mL)+10% glucose (35 mL) using micro pump within 20 min. For those with Visual Analogy Scale (VAS) pain score > 4.0, a second infusion and topical 2.5% CG gel were given. VAS pain scores were measured before infusion, immediately after the first infusion, 4 h after the first infusion, 4 h after the second infusion, and the next day. Dynamic changes of blood electrolytes and urinary fluoride, wound healing time, treatment outcome, and adverse reactions were observed.

    Results Thirty-eight patients received single infusion, and the average VAS pain scores before infusion, immediately after infusion, 4 h after infusion, and of the next day were 6.82±1.27, 3.78±1.77, 2.81±1.31, and 1.93±0.97, respectively (F=93.03, P < 0.01); nine patients received two infusions, and the average VAS scores before infusion, immediately after the first infusion, 4 h after the first infusion, 4 h after the second infusion, and of the next day were 7.62±1.31, 4.72±0.99, 4.44±0.48, 3.01±0.65, and 2.99±0.80, respectively (F=40.25, P < 0.01). After infusion, urinary fluoride showed a trend of decline (F=10.49, P < 0.01), and blood calcium increased after each infusion (F=8.60, P < 0.01). Except one case whose blood calcium was higher than the reference value after the second infusion, the other patients' blood calcium levels were within the reference range and no severe adverse reaction was reported. Thirty-eight patients were healed after subsequent dressing treatment, and the other nine patients were healed after skin grafting or skin flap repair.

    Conclusion Arterial infusion of CG is an effective and safe treatment of hydrofluoric acid burns of hand, with few side effects.

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