HUANG Zi-yi, CHEN Duo, YE Xin-yu, WU Pian, HE Ya-yuan, DING Ping. Effects of exposure to edible oil with different heating time on blood lipids and trace elements in male mice[J]. Journal of Environmental and Occupational Medicine, 2018, 35(5): 418-422. DOI: 10.13213/j.cnki.jeom.2018.17638
Citation: HUANG Zi-yi, CHEN Duo, YE Xin-yu, WU Pian, HE Ya-yuan, DING Ping. Effects of exposure to edible oil with different heating time on blood lipids and trace elements in male mice[J]. Journal of Environmental and Occupational Medicine, 2018, 35(5): 418-422. DOI: 10.13213/j.cnki.jeom.2018.17638

Effects of exposure to edible oil with different heating time on blood lipids and trace elements in male mice

  • Objective To assess the effects of exposure to edible oil with different heating time on blood lipids and trace elements in male mice.

    Methods Forty male Kunming mice were divided into five groups, with eight rats in each group. The control group received intragastric administration of distilled water, and the four exposure groups received intragastric administration of unheated edible oil and edible oil heated for 1 h, 3 h, and 9 h, respectively, at 0.015 mL/g per day. After six weeks of exposure, eyeball blood samples were collected to isolate serum. The levels of triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), and lowdensity lipoprotein (LDL) were detected by ELIZA, and the levels of chromium (Cr), manganese (Mn), and iron (Fe) by atomic absorption spectrophotometry.

    Results After exposure to edible oil with designed heating durations, the LDL level, Cr level, and LDL/HDL ratio in serum were significantly different among the groups (P < 0.05). Compared with the unheated edible oil group, the 9h-heated edible oil group showed increased LDL level and LDL/HDL ratio and decreased Cr level (Ps < 0.05). No differences in TC, TG, HDL, Mn, and Fe were found among the groups (P>0.05).

    Conclusion Exposure to edible oil heated for up to 9h may lead to increased LDL level and LDL/HDL ratio and decreased Cr level.

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