ZHANG Tao, WANG Qing-ling, GE Jian-mei, ZOU Zhonglan, WANG Da-peng, SUN Bao-fei, WEI Shao-feng, LI Jun, ZHANG Ai-hua. Characteristics of blood routine indices, urine routine indices, and biochemical indices of liver and kidney in patients with coal-burning arsenism[J]. Journal of Environmental and Occupational Medicine, 2018, 35(12): 1089-1093, 1099. DOI: 10.13213/j.cnki.jeom.2018.18347
Citation: ZHANG Tao, WANG Qing-ling, GE Jian-mei, ZOU Zhonglan, WANG Da-peng, SUN Bao-fei, WEI Shao-feng, LI Jun, ZHANG Ai-hua. Characteristics of blood routine indices, urine routine indices, and biochemical indices of liver and kidney in patients with coal-burning arsenism[J]. Journal of Environmental and Occupational Medicine, 2018, 35(12): 1089-1093, 1099. DOI: 10.13213/j.cnki.jeom.2018.18347

Characteristics of blood routine indices, urine routine indices, and biochemical indices of liver and kidney in patients with coal-burning arsenism

  • Objective To detect urine arsenic content, blood/urine routine indices, and liver and kidney biochemical indices of patients with coal-burning arsenism, and preliminarily understand their health status.

    Methods In March 2017, a coal-burning arsenism area in Yuzhang Town of Guizhou was selected for investigation. According to the Diagnostic Criteria for Endemic Arsenism (WS/T 211-2015), 200 arsenism patients were diagnosed, and they were further divided into a mild arsenism group (n=59), a moderate arsenism group (n=70), and a severe arsenism group (n=71) according to skin damage. Another 40 non-arsenic exposed residents with similar living habits but living 12 km away from the endemic area were selected as the control group. Inductively coupled plasma mass spectrometry was used to detect arsenic content in urine samples, full automatic blood/urine analyzers were used to measure blood/urine routine test indices, and automatic biochemical analyzer was used to detect biochemical indices of liver and kidney.

    Results Urine arsenic levels in the mild, moderate, and severe coal-burning arsenism groups were (27.59±19.72), (25.58±17.78), and (31.72±22.79)μg/L·Cr, respectively, and all were higher than the level in the control group (P < 0.05). The abnormal rates of white blood cells (13.6%, 14.3%, 15.5%), neutrophils (13.6%, 15.7%, 16.9%), mean corpuscular volume (44.1%, 47.1%, 49.3%), mean corpuscular hemoglobin concentration (28.8%, 27.1%, 29.6%), and platelet distribution width (22.0%, 28.6%, 31.0%) in blood routine test of the mild, moderate, and severe arsenism groups were higher than the corresponding rates of the control group (P < 0.05), respectively, and there were no statistical differences in the above indices among the three arsenism groups (P > 0.05). There were no significant differences in the abnormal rates of urine routine indices among the four groups (P > 0.05). The total protein(79.54±5.01), (77.69±6.04), (76.08±5.73) g/L, albumin(47.23±3.35), (44.10±4.34), (42.30±3.76) g/L, and albumin/globulin (1.48±0.27, 1.33±0.19, 1.27±0.23) in the liver biochemical test of the mild, moderate, and severe groups all were lower than those of the control group (P < 0.05); the cholinesterase levels(9 618±1 942), (9 600±2 273) U/L of the moderate and severe groups were lower than that of the control group (P < 0.05); the total protein of the severe group was lower than that of the mild group (P < 0.05); albumin, albumin/globulin, and cholinesterase of the moderate and severe groups were lower than those of the mild group (P < 0.05). In the renal biochemical test, the urea nitrogen levels of the mild, moderate, and severe groups(5.10±1.29), (5.24±1.20), (5.13±1.27) mmol/L were higher than that in the control group (P < 0.05); the serum creatinine levels in the moderate and severe patients(67.40±12.32), (69.03±13.14) mmol/L were higher than those in the control group (P < 0.05); the serum creatinine levels of the moderate and severe groups were significantly higher than that in the mild group (P < 0.05).

    Conclusion The urinary arsenic levels of some patients in this coal-burning arsenism area is higher than that of local controls, and their blood routine test and liver/kidney biochemical indices are abnormal. It suggests that low arsenic pollution and its chronic damage to other organs other than skin should not be ignored, and continuously strengthening the supervision of arsenic pollution and paying attention to the occurrence and development of chronic diseases in arsenism patients are important to the prevention and early targeted treatment of the disease.

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