YU Peipei, JIAO Jie, GU Gui-zhen, CHEN Guo-shun, ZHANG Huan-ling, ZHOU Wen-hui, WU Hui, LI Yanhong, ZHENG Yu-xin, YU Shan-fa. Association between SOD2 polymorphisms and susceptibility to noise-induced hearing loss[J]. Journal of Environmental and Occupational Medicine, 2018, 35(12): 1069-1075. DOI: 10.13213/j.cnki.jeom.2018.18387
Citation: YU Peipei, JIAO Jie, GU Gui-zhen, CHEN Guo-shun, ZHANG Huan-ling, ZHOU Wen-hui, WU Hui, LI Yanhong, ZHENG Yu-xin, YU Shan-fa. Association between SOD2 polymorphisms and susceptibility to noise-induced hearing loss[J]. Journal of Environmental and Occupational Medicine, 2018, 35(12): 1069-1075. DOI: 10.13213/j.cnki.jeom.2018.18387

Association between SOD2 polymorphisms and susceptibility to noise-induced hearing loss

  • Objective To explore the association between superoxide dismutase gene 2 (SOD2) polymorphisms and the susceptibility to noise-induced hearing loss (NIHL).

    Methods A 1:2 matched nested case-control study was conducted based on the cohort established in 2006 of workers with noise exposure in a steel factory, and a total of 190 NIHL cases and 380 controls were chosen according to the matching standards of same gender, same type of work, age difference ≤5 years, and noise exposure duration ≤2 years. The single nucleotide polymorphisms (SNPs) of rs2758343, rs2758346, rs4880, and rs5746105 in SOD2 were genotyped by high throughput SNP genotyping assay. Codominant, dominant, and recessive models were established to study SOD2 polymorphisms and the susceptibility to NIHL by single-factor conditional logistic regression analysis. The risk of NIHL in individuals with different genotypes along with the extending of noise exposure duration was analyzed by COX regression analysis. The interactive effect among the four SNPs was analyzed by GMDR v0.9 software.

    Results The risk of NIHL in individuals with AA genotype of rs5746105 was 1.50 times of those with GG and GA genotypes (95%CI:1.02-2.21). With the increase of noise exposure duration, individuals with AA genotype of rs5746105 had a higher risk of NIHL than those with GG genotype (HR=1.67, 95%CI:1.08-2.57) and those with GG and GA genotypes (HR=1.42, 95%CI:1.04-1.94). The results of optimal gene-gene interaction model did not show interactions among the four SNPs in SOD2 (P > 0.05).

    Conclusion The mutant allele A of rs5746105 in SOD2 may be a risk factor of NIHL.

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