YUAN Bao-jun, LI Chao, WANG Yu-han, TONG Yan-yan, ZHANG Shu-lan, LI Yong-zhe. Levels and significance of peripheral leukocyte subsets in patients with stage I coal workers' pneumoconiosis[J]. Journal of Environmental and Occupational Medicine, 2018, 35(1): 49-54. DOI: 10.13213/j.cnki.jeom.2017.17510
Citation: YUAN Bao-jun, LI Chao, WANG Yu-han, TONG Yan-yan, ZHANG Shu-lan, LI Yong-zhe. Levels and significance of peripheral leukocyte subsets in patients with stage I coal workers' pneumoconiosis[J]. Journal of Environmental and Occupational Medicine, 2018, 35(1): 49-54. DOI: 10.13213/j.cnki.jeom.2017.17510

Levels and significance of peripheral leukocyte subsets in patients with stage I coal workers' pneumoconiosis

  • Objective To explore the changes and significance of peripheral leukocyte subsets in patients with stage I coal workers' pneumoconiosis (CWP).

    Methods Levels of peripheral leukocyte subsets were determined in 66 patients with diagnosis of stage I CWP (CWP group), 47 healthy underground coal workers with the same dust exposure as the CWP group (dust-exposed group), and 40 healthy ground coal workers without dust exposure (non-dust-exposed group) by five-color flow cytometry. The CWP group was further evaluated based on smoking, complication, duration of exposure to dust, and pulmonary function impairment.

    Results Compared with the non-dust-exposed group3.76% (2.97%-4.94%), 5.63% (4.69%-6.63%), 6.12% (5.14%-7.21%), 2.07% (1.28%-3.03%), and 0.79% (0.58%-0.98%), the levels of B lymphocytes, CD16-monocytes, total monocytes, eosinophils, and basophils in the CWP group4.47% (3.41%-5.92%), 6.47% (5.71%-7.81%), 6.88% (6.18%-8.45%), 2.70%(2.07%-3.80%), and 0.97% (0.76%-1.22%) were significantly increased (P < 0.05). Compared with dust-exposed group3.94% (3.25%-4.59%), 2.04% (1.13%-3.29%), 7.50% (5.91%-11.13%), the levels of B lymphocytes and eosinophils4.47% (3.41%-5.92%), 2.70% (2.07%-3.80%) in the CWP group were increased, whereas the level of cytotoxic T+NK cells6.44% (4.47%-9.16%) was decreased (P < 0.05). The levels of cytotoxic T+NK cells, total monocytes, and CD16-monocytes in the dust-exposed group were significantly higher than those in the non-dust-exposed group (P < 0.05). Neutrophils were not different among the three groups (P > 0.05). For the CWP group, increased levels of peripheral total lymphocytes and B lymphocytes and decreased level of mature neutrophils were found in the smoking patients compared with the non-smoking patients (P < 0.05). There were no differences in leukocyte subsets among patients grouped by other clinical indicators (P > 0.05).

    Conclusion Abnormal levels of peripheral leukocyte subsets (B lymphocytes, cytotoxic T+NK cells, and eosinophils) are identified in the stage I CWP patients, which may be contributed by smoking.

  • loading

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return