Carcinogenicity of trichloroethylene
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Abstract
Trichloroethylene is a widely used industrial solvent and a common environmental contaminant. In animal experiments, trichloroethylene is found to cause liver cancer in mice and kidney cancer in rats. Epidemiological studies show associations of trichloroethylene exposure with a variety of cancers, including liver and kidney cancers. In 2012, trichloroethylene was classified as Group I, a known human carcinogen, by IARC based on its well-documented effects on kidney cancer, but the effects of trichloroethylene on liver cancer and the molecular mechanism of trichloroethylene carcinogenesis remained unclear. This article reviewed the latest research advances and our laboratory work, and discussed the effects of trichloroethylene on kidney and liver cancers in terms of epidemiological studies, animal experiments, and molecular mechanisms.
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