蔡任之, 钱耐思, 虞慧婷, 钱轶峰, 王春芳. 母亲孕中期空气污染暴露与新生儿出生体重的相关性[J]. 环境与职业医学, 2017, 34(6): 479-482. DOI: 10.13213/j.cnki.jeom.2017.16800
引用本文: 蔡任之, 钱耐思, 虞慧婷, 钱轶峰, 王春芳. 母亲孕中期空气污染暴露与新生儿出生体重的相关性[J]. 环境与职业医学, 2017, 34(6): 479-482. DOI: 10.13213/j.cnki.jeom.2017.16800
CAI Ren-zhi, QIAN Nai-si, YU Hui-ting, QIAN Yi-feng, WANG Chun-fang. Association between maternal air pollution in second trimester and birth weight[J]. Journal of Environmental and Occupational Medicine, 2017, 34(6): 479-482. DOI: 10.13213/j.cnki.jeom.2017.16800
Citation: CAI Ren-zhi, QIAN Nai-si, YU Hui-ting, QIAN Yi-feng, WANG Chun-fang. Association between maternal air pollution in second trimester and birth weight[J]. Journal of Environmental and Occupational Medicine, 2017, 34(6): 479-482. DOI: 10.13213/j.cnki.jeom.2017.16800

母亲孕中期空气污染暴露与新生儿出生体重的相关性

Association between maternal air pollution in second trimester and birth weight

  • 摘要: 目的 研究母亲孕中期可吸入颗粒物(PM10)、二氧化硫(SO2)、二氧化氮(NO2)暴露对新生儿出生体重的影响。

    方法 依据2008—2012年上海市出生登记系统资料以及上海市环境监测中心在网络上发布的每日PM10、SO2及NO2(2007—2012年)等污染物数据,进行回顾性队列研究。共纳入婴儿96.43万,根据母亲孕周和分娩日期计算每位母亲孕中期污染物暴露水平。经比较婴儿及其母亲不同人口学特征间差异,初步发现出生体重的影响因素;用多元回归分析孕中期污染物与出生体重的关系,并且研究在3种污染物互相协同或拮抗的情况下,其对出生体重的影响。

    结果 母亲孕中期3种污染物暴露对新生儿出生体重的影响均呈负效应。单因素模型中,孕中期暴露PM10和SO2的平均质量浓度每增加10 μg/m3,新生儿出生体重分别减少4.4 g和1.1 g。在双污染物模型中,在SO2或NO2存在的情况下,PM10对出生体重的影响,比其单独存在时更明显。在三污染物模型中,3种污染物同时存在时,孕中期暴露PM10和SO2的平均质量浓度每增加10 μg/m3,新生儿出生体重分别减少20.7 g和3.5 g。

    结论 母亲孕中期空气污染物暴露与新生儿出生体重相关,空气污染对妊娠结局的影响值得关注。

    Objective To study the association of birth weight with maternal exposure to air pollutants in the second trimester, including particulate matter ≤ 10 μm in aerodynamic size (PM10), sulphur dioxide (SO2), and nitrogen dioxide (NO2).

     

    Abstract: Methods Based on the data from Shanghai birth registry system from 2008 to 2012 and the daily air pollution records of PM10, SO2, and NO2 from 2007 to 2012 from Shanghai Environmental Monitoring Center, a retrospective cohort study involving 964.3 thousand newborns was conducted to calculate individual level of maternal exposure to selected air pollutants during the second trimester by gestation week and delivery date. Influencing factors of birth weight were identified through comparing the demographic characteristics of infants and mothers, and the association between air pollutant exposure in the second trimester and birth weight was assessed by multiple linear regression analysis.

    Results Maternal exposure to the studied three pollutants in the second trimester showed negative effects on birth weight. According to the one-pollutant models, the birth weight was reduced by 4.4 g and 1.1 g for each 10 μg/m3 increase of PM10 and SO2, respectively. According to the two-pollutant models, the impact of PM10 combined with either SO2 or NO2 on birth weight was greater than PM10 alone. According to the three-pollutant model, birth weight was reduced by 20.7 g for each 10 μg/m3 increase of PM10, and 3.5 g for each 10 μg/m3 increase of SO2.

    Conclusion Maternal air pollutant exposure in the second trimester is associated with birth weight. The impact of air pollution on pregnancy outcomes should be concerned.

     

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