袁静宜, 匡兴亚. 大气颗粒物及其组分对肾脏影响的研究进展[J]. 环境与职业医学, 2021, 38(3): 314-320. DOI: 10.13213/j.cnki.jeom.2021.20376
引用本文: 袁静宜, 匡兴亚. 大气颗粒物及其组分对肾脏影响的研究进展[J]. 环境与职业医学, 2021, 38(3): 314-320. DOI: 10.13213/j.cnki.jeom.2021.20376
YUAN Jingyi, KUANG Xingya. Research progress on effects of airborne particulate matters and constituents on kidney[J]. Journal of Environmental and Occupational Medicine, 2021, 38(3): 314-320. DOI: 10.13213/j.cnki.jeom.2021.20376
Citation: YUAN Jingyi, KUANG Xingya. Research progress on effects of airborne particulate matters and constituents on kidney[J]. Journal of Environmental and Occupational Medicine, 2021, 38(3): 314-320. DOI: 10.13213/j.cnki.jeom.2021.20376

大气颗粒物及其组分对肾脏影响的研究进展

Research progress on effects of airborne particulate matters and constituents on kidney

  • 摘要:

    大气颗粒物对人体的健康损害已成为研究热点,对心肺系统产生的直接不良影响已被熟知,随着研究的深入,学者们逐渐将重心转向其他靶器官,尤其是肾脏。但大气颗粒物及其组分对肾脏的影响和作用机制尚不明确,本文以全颗粒物及其组分为出发点,分别从流行病学及实验研究两方面探讨其与肾损伤间的关联,在此基础上从氧化应激与炎症损伤、细胞DNA损伤、内质网应激以及细胞自噬四方面对颗粒物引起肾损伤的机制进行综述。

     

    Abstract:

    The health damage of airborne particulate matters (PM) has become a popular research topic, and its direct adverse effect on cardiopulmonary system has been well recognized. As the research goes deeper, scientists have refocused towards other target organs, especially the kidney. However, the effects and mechanisms of PM and its constituents on the kidney have not been elaborated. From the perspective of whole PM and its constituents, the associations with kidney damage were summarized from epidemiological and toxicological studies, and then the studied potential mechanisms such as oxidative stress and inflammation, DNA damage, endoplasmic reticulum stress, and cell autophagy through which PM induce kidney damage were reviewed.

     

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