夏永鹏, 孙文均. 草甘膦农药生殖毒性的研究进展[J]. 环境与职业医学, 2020, 37(12): 1230-1238. DOI: 10.13213/j.cnki.jeom.2020.20251
引用本文: 夏永鹏, 孙文均. 草甘膦农药生殖毒性的研究进展[J]. 环境与职业医学, 2020, 37(12): 1230-1238. DOI: 10.13213/j.cnki.jeom.2020.20251
XIA Yong-peng, SUN Wenjun. Study advances on reproductive toxicity induced by glyphosate[J]. Journal of Environmental and Occupational Medicine, 2020, 37(12): 1230-1238. DOI: 10.13213/j.cnki.jeom.2020.20251
Citation: XIA Yong-peng, SUN Wenjun. Study advances on reproductive toxicity induced by glyphosate[J]. Journal of Environmental and Occupational Medicine, 2020, 37(12): 1230-1238. DOI: 10.13213/j.cnki.jeom.2020.20251

草甘膦农药生殖毒性的研究进展

Study advances on reproductive toxicity induced by glyphosate

  • 摘要:

    草甘膦是全球生产和使用量最大的除草剂,在环境中有着较高的残留水平。已有研究结果显示,草甘膦暴露可导致肝肾毒性、神经毒性等健康危害,并具有一定的致癌性。此外,现有的研究结果表明,低浓度的草甘膦暴露会影响性激素的合成分泌,破坏生殖系统的功能结构,干扰配子的发育成熟,并导致不良妊娠结局的发生等不良效应,提示草甘膦具有一定的生殖毒性。因此,草甘膦的生殖毒性引起了公众广泛的关注,但具体的生殖健康损害表现及其潜在的分子机制尚不明确。本文对近年来有关草甘膦生殖毒性的研究进行综述,分别探讨了草甘膦暴露对雄性哺乳动物、雌性哺乳动物和非哺乳动物的生殖毒性,并从内分泌干扰效应、氧化应激、表观遗传修饰等方面分析草甘膦诱导生殖毒性的可能分子机制,旨在全面阐述草甘膦生殖毒性的研究现状及其进展,为草甘膦暴露对公众健康影响的科学评估及其后续的研究提供依据。

     

    Abstract:

    Glyphosate is the most produced and widely used herbicide in the world, and has been reported a high residue level in the environment. Studies have shown that glyphosate exposure can lead to various health hazards, including liver and kidney toxicity, neurotoxicity, and even carcinogenicity. In addition, ever-growing studies have demonstrated that exposure to low concentrations of glyphosate may impact the synthesis and secretion of sex hormones, impair the functional structure of the reproductive system, interfere with the development and maturation of gametes, and lead to adverse pregnancy outcomes, suggesting that glyphosate has reproductive toxicity. Thus, the reproductive toxicity of glyphosate has aroused widespread concern, but the specific manifestations of reproductive health damage and its potential molecular mechanisms are still unclear. This review summarized recent studies on the reproductive toxicity of glyphosate in male mammals, female mammals, and non-mammalians. In addition, the possible molecular mechanisms of glyphosate to induce reproductive toxicity were analyzed from the aspects of endocrine interference effect, oxidative stress, and epigenetic modification. This review aimed to comprehensively evaluate the present status and advances on studies of reproductive toxicity of glyphosate, and provide a scientific basis for glyphosate health risk assessment and further exploring its reproductive health hazard.

     

/

返回文章
返回