陈绩, 李彤, 吴限好, 王宇, 金迎, 林楠. 全氟和多氟烷基化合物暴露特征与健康效应研究进展[J]. 环境与职业医学, 2023, 40(8): 958-964. DOI: 10.11836/JEOM22444
引用本文: 陈绩, 李彤, 吴限好, 王宇, 金迎, 林楠. 全氟和多氟烷基化合物暴露特征与健康效应研究进展[J]. 环境与职业医学, 2023, 40(8): 958-964. DOI: 10.11836/JEOM22444
CHEN Ji, LI Tong, WU Xianhao, WANG Yu, JIN Ying, LIN Nan. Review on exposure characteristics and health effects of per- and poly-fluoroalkyl substances[J]. Journal of Environmental and Occupational Medicine, 2023, 40(8): 958-964. DOI: 10.11836/JEOM22444
Citation: CHEN Ji, LI Tong, WU Xianhao, WANG Yu, JIN Ying, LIN Nan. Review on exposure characteristics and health effects of per- and poly-fluoroalkyl substances[J]. Journal of Environmental and Occupational Medicine, 2023, 40(8): 958-964. DOI: 10.11836/JEOM22444

全氟和多氟烷基化合物暴露特征与健康效应研究进展

Review on exposure characteristics and health effects of per- and poly-fluoroalkyl substances

  • 摘要: 全氟和多氟烷基化合物(PFAS)是一类近年来备受关注的新型持久性有机污染物。本文综述了包括新型替代物在内的PFAS的人群暴露特征与潜在健康效应。现有研究发现,人群主要通过摄食暴露于PFAS,食物和饮用水是其中最重要的来源。在暴露特征上,地理、性别、年龄和职业差异通过影响人群的行为特征和代谢水平等,进一步影响对应人群体内PFAS暴露水平,其中职业暴露受到较多关注,尤其在新型PFAS的发现上。PFAS具有肝肾毒性、免疫毒性、生殖毒性、代谢异常、神经毒性和致癌性等,可对人体健康造成多种不良影响。但其中部分结论并不完全一致,且人群流行病学研究多聚焦儿童和年轻人群,缺少老年人群的相关数据。未来研究可更多关注老年人群,并对存在争议的结论开展验证性探索。

     

    Abstract: Per- and poly-fluoroalkyl substances (PFAS) are a new type of persistent organic pollutants that have received extensive attention in recent years. This article reviewed the population characteristics of environmental exposure to PFAS, as well as the potential health effects. Previous studies have verified that people are exposed to PFAS mainly through ingestion, and food and water are the dominant contributors. In terms of exposure characteristics, geographical, gender, age, and occupational differences have an impact on the level of PFAS exposure in the corresponding populations by influencing their behavioral characteristics and metabolic levels, with occupational exposure receiving more attention, especially in the exploration of novel PFAS. PFAS associate with a variety of adverse health effects caused by hepatorenal toxicity, immunotoxicity, reproductive toxicity, neurotoxicity, and carcinogenicity. However, some of the conclusions are not completely consistent, and the published epidemiological studies have focused on children and young people, lacking relevant data of the elderly. Future research can pay more attention to the elderly population and carry out validation exploration on controversial conclusions.

     

/

返回文章
返回