膳食营养、生活方式与帕金森病关联的研究进展

Recent progress on associations of dietary nutrition and lifestyle with Parkinson's disease

  • 摘要: 随着我国进入深度老龄社会,帕金森病(PD)患病形势持续加重,严重威胁着我国中老年居民的身心健康和生活质量,也给提高健康预期寿命、实现健康中国战略目标带来了巨大挑战。既往研究发现膳食营养和生活方式与PD的发生发展存在关联,提示红肉过多摄入可能会增加PD患病风险,咖啡和茶、膳食抗氧化维生素、n-3多不饱和脂肪酸、维生素D和B族维生素可能与降低PD患病风险或延缓PD进展相关,以新鲜蔬菜和水果、豆类、全谷物及鱼类、禽肉摄入较多的膳食模式也与PD患病风险降低相关,此外,积极地进行身体活动是PD的保护因素,而吸烟也与PD患病风险降低相关,但其中机制仍不明确。本文通过对既往文献进行综述,回顾了食物、营养素、膳食模式和生活方式与PD的关联并总结了相关研究的局限性,为PD防控关口前移提供一定的依据。

     

    Abstract: With the expansion of aging population in China, the increasingly serious situation of Parkinson's disease (PD) threatens the physical and mental health and quality of life of middle-aged and elderly people, posing a great challenge to increase healthy life expectancy and realize the Healthy China Strategy. Previous studies showed some connections between dietary and lifestyle factors and PD and suggested that excessive intake of red meat might increase the risk of PD; however, coffee and tea, dietary antioxidants, n-3 polyunsaturated fatty acids, vitamin D, and vitamin B were associated with reducing the risk of PD or delaying the progression of PD, and dietary patterns with high intakes of fresh vegetables and fruits, legumes, whole grains, fish, and poultry meat were also associated with a reduced risk of PD. In addition, physical activity was a protective factor for PD, and smoking was also associated with a reduced risk of PD, but the related mechanisms were still unclear. This paper evaluated the relationships of factors like foods, nutrients, dietary patterns, and lifestyle with PD based on published literature, summarized the limitations of relevant studies, and provided useful enlightenment for PD prevention and control.

     

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